Zaleplon

Base Information Edit

Chemical Name:Zaleplon
CAS No.:151319-34-5
Molecular Formula:C17H15N5O
Molecular Weight:305.339
Hs Code.:2933595960
European Community (EC) Number:604-794-5
UNII:S62U433RMH
DSSTox Substance ID:DTXSID5023748
Nikkaji Number:J575.185C
Wikipedia:Zaleplon
Wikidata:Q145052
NCI Thesaurus Code:C29551
RXCUI:74667
Pharos Ligand ID:7GPBLRS7A27Q
Metabolomics Workbench ID:43218
ChEMBL ID:CHEMBL1521
Mol file:151319-34-5.mol

Synonyms:3'-(3-cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide;CL 284,846;CL 284846;CL-284846;CL284,846;L 846;L-846;N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide;SKP-1041;Sonata;Starnoc;zaleplon;Zelepion

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Zaleplon Edit

Chemical Property:

Appearance/Colour:off-white powder
Melting Point:186-187 °C
Refractive Index:1.655
PKA:-1.47±0.50(Predicted)
Flash Point:9℃
PSA：74.29000
Density:1.25 g/cm³
LogP:2.64078
Storage Temp.:2-8°C
Solubility.:DMSO: ~20mg/mL
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:305.12766012
Heavy Atom Count:23
Complexity:487

Purity/Quality:

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T,F
Statements: 36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-36/37-16-7

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Sedatives and Hypnotics
Canonical SMILES:CCN(C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C#N)C(=O)C
Recent ClinicalTrials:Cerebral MRI During Sleep
Description Zaleplon was introduced in Sweden and Denmark as a new treatment for insomnia, particularly in patients who have difficulty in falling asleep. Zaleplon is a non-benzodiazepine compound and is the first in a new generation belonging to the pyrazolopyrimidine class, showing therefore fewer benzodiazepine-like side effects. It can be synthesized in 3 steps from the corresponding acetophenone, the key step being the cyclization of the appropriate enaminone with 3-aminopyrazole-4-carbonitrile. Biochemically, Zaleplon is a full agonist at the benzodiazepine o)1 site of the gaba-A receptor complex, but its behavioural profile remains distinct from both benzodiazepine (e.g. Lorazepam) or non-benzodiazepine (e.g. Zopiclone or Zolpidem) sedativehypnotic drugs. Clinical pharmacokinetic analysis showed rapid absorption and elimination. In man, the main metabolic route was oxidative giving the major metabolites 5-oxo Zaleplon and its N-desethyl analog. Both were shown to have no effect at central benzodiazepine receptors and to be rapidly excreted as glucuronides. In patients with chronic insomnia, Zaleplon at 5 and 10 mg/kg significantly reduced sleep latency and improved the quality of sleep compared with placebo without altering the normal sleep architecture. Given its short halflife, the next-day residual effects such as hangover are minimized. It may have some advantages over benzodiazepines regarding unwanted amnesic effects and psychomotor impairment. There was no evidence for the occurrence of rebound insomnia at 10 mg/kg. Zaleplon (Item No. 11577) is an analytical reference material that is functionally categorized as a sedative. It is a pyrazolopyrimidine that selectively activates the GABAA α1 receptor subunit (EC50 = 1.1 μM), producing a sedative effect. It is characterized as being an ultra-short-acting sedative due to short Tmax (0.7-1.4 hours) and half-life (1 hour) values. This product is intended for research and forensic applications.
Uses Selective non-benzodiazepine GABAA receptor agonist
Therapeutic Function Sedative

Technology Process of Zaleplon

There total 15 articles about Zaleplon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%