N,N-dimethyl-4-methoxyphenylethylamine

Base Information

• Chemical Name: N,N-dimethyl-4-methoxyphenylethylamine
• CAS No.: 775-33-7
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.262
• Mol file: 775-33-7.mol

Synonyms:Phenethylamine,p-methoxy-N,N-dimethyl- (7CI,8CI); 4-Methoxy-N,N-dimethylphenethylamine;N,N-Dimethyl-2-(p-anisyl)ethylamine; N,N-Dimethyl-4-methoxyphenethylamine;p-Methoxy-N,N-dimethylphenethylamine

Chemical Property of N,N-dimethyl-4-methoxyphenylethylamine

Chemical Property:

• Vapor Pressure: 0.0168mmHg at 25°C
• Melting Point: 115-117 °C
• Boiling Point: 254.9°C at 760 mmHg
• PKA: 9.57±0.22(Predicted)
• Flash Point: 74.5°C
• PSA: 12.47000
• Density: 0.961g/cm³
• LogP: 1.79930
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Very Slightly), Chloroform (Slightly)

Purity/Quality:

99%+, ^*data from raw suppliers

Des(1-cyclohexanol)Venlafaxine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Des(1-cyclohexanol) Venlafaxine (Venlafaxine EP Impurity A) is a Venlafaxine (V119995) impurity. Venlafaxine (V119995) impurity.

Technology Process of N,N-dimethyl-4-methoxyphenylethylamine

There total 14 articles about N,N-dimethyl-4-methoxyphenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-Methoxyphenethylamine (55-81-2) → 4-methoxyphenethyl-dimethylamine (775-33-7)

Guidance literature:

With formic acid; In water; for 3h; Heating;

DOI:10.1016/S0040-4020(01)97202-3

Reference yield: 92.0%

2-(4-Methoxyphenyl)ethanol (702-23-8) + dimethyl amine (124-40-3) → 4-methoxyphenethyl-dimethylamine (775-33-7)

Guidance literature:

With C₁₉H₃₂Cl₂IrN₂; potassium carbonate; In water; at 120 ℃; for 40h; Sealed tube; Green chemistry;

DOI:10.1021/acs.joc.0c02896

Reference yield: 41.0%

dimethyl amine (124-40-3) + 1-(2-Chloroethyl)-4-methoxybenzene (18217-00-0) → 4-methoxyphenethyl-dimethylamine (775-33-7)

Guidance literature:

In methanol; Ambient temperature;

DOI:10.1248/cpb.32.4185

upstream raw materials:

N,N-dimethyl(4-methoxyphenyl)thioacetamide

formaldehyd

4-Methoxyphenethylamine

p-methoxybenzylnitrile

Downstream raw materials:

N,N-dimethyltyramine

(4-methoxy-phenethyl)-trimethyl-ammonium; chloride

1-(2'-methoxyhordeninyl)-3-methyl-1,3-butadiene

4-(2'-methoxyhordeninyl)-(E)-2-methylbut-3-en-2-ol

Refernces

• 1、 Paul, Bhaskar,Shee, Sujan,Chakrabarti, Kaushik,Kundu, Sabuj. "Tandem Transformation of Nitro Compounds into N-Methylated Amines: Greener Strategy for the Utilization of Methanol as a Methylating Agent". . p. 2370 - 2374. Retrieved 2017/06/13.
• 2、 Guyon, Carole,Duclos, Marie-Christine,Métay, Estelle,Lemaire, Marc. "Reductive N-methylation of amines with calcium hydride and Pd/C catalyst". . p. 3002 - 3005. Retrieved 2016/07/06.