C₁₅H₁₆N₂O

Base Information

• Chemical Name: C₁₅H₁₆N₂O
• CAS No.: 1290176-49-6
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.305
• Mol file: 1290176-49-6.mol

Synonyms:C₁₅H₁₆N₂O

Chemical Property of C₁₅H₁₆N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₆N₂O

There total 1 articles about C₁₅H₁₆N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4,5,6,7-tetrahydro-1H-benzimidazole (3752-24-7) + 4-methyl-benzoyl chloride (874-60-2) → C15H16N2O (1290176-49-6)

Guidance literature:

4,5,6,7-tetrahydro-1H-benzimidazole; 4-methyl-benzoyl chloride; With triethylamine; In pyridine; at 40 ℃;

With sodium hydroxide; In water;

DOI:10.1016/j.bmcl.2011.02.032

Reference yield: 99.0%

C15H16N2O (1290176-49-6) + allyl bromide (106-95-6) → (1-allyl-4,5,6,7-tetrahydro-1H-benzimidazole-2-yl)[4-methylphenyl]methanone (840503-10-8)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; at 40 ℃;

DOI:10.1016/j.bmcl.2011.02.032

Reference yield:

C15H16N2O (1290176-49-6) → C32H38N2O4

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 ether; potassium carbonate / tetrahydrofuran / 40 °C

2: N-Methyldicyclohexylamine; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 70 °C

With 18-crown-6 ether; N-Methyldicyclohexylamine; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Heck reaction;

DOI:10.1016/j.bmcl.2011.02.032

upstream raw materials:

4,5,6,7-tetrahydro-1H-benzimidazole

4-methyl-benzoyl chloride

Downstream raw materials:

(1-allyl-4,5,6,7-tetrahydro-1H-benzimidazole-2-yl)[4-methylphenyl]methanone

Refernces