Multi-step reaction with 11 steps
1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C
2: acetic acid; iron / acetic acid / 0.5 h / 90 °C
3: 0.5 h / 0 - 20 °C
4: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 16 h / 120 °C
5: water; calcium chloride; iron / ethanol / 4 h / 100 °C
6: potassium fluoride / N,N-dimethyl-formamide / 4 h / 150 °C
7: water; calcium chloride; iron / ethanol / 4 h / 100 °C
8: 0.5 h / 100 °C
9: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C
10: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C
11: pyridine / dichloromethane / 4 h
With
pyridine; copper(I) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; iron; sodium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; calcium chloride;
In
1,2-dimethoxyethane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;