Tosufloxacin tosylate

Base Information

• Chemical Name: Tosufloxacin tosylate
• CAS No.: 115964-29-9
• Deprecated CAS: 144742-63-2
• Molecular Formula: C₇H₈O₃S*C₁₉H₁₅F₃N₄O₃
• Molecular Weight: 576.553
• Hs Code.: 29339900
• UNII: NO6NM634EH
• DSSTox Substance ID: DTXSID8047842
• Wikidata: Q27147207
• NCI Thesaurus Code: C76234
• ChEMBL ID: CHEMBL104270
• Mol file: 115964-29-9.mol

Synonyms:7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid;7-(3-aminopyrrolin-1-yl)-1-(2,4-diflurophenyl)-1.4-dihydro-6-fluoro-4-oxo-1,8-napthyridine-3-carboxylic acid;A 60969;A 61827;A-60969;A-61827;A-64730;T 3262;T-3262;tosufloxacin;tosufloxacin citric anhydride;tosufloxacin tosilate;tosufloxacin, 4-toluene sulfonate

Chemical Property of Tosufloxacin tosylate

Chemical Property:

• Appearance/Colour: White to off-white solid
• Vapor Pressure: 5.96E-16mmHg at 25°C
• Melting Point: 251-252 °C
• Boiling Point: 614.4 °C at 760 mmHg
• Flash Point: 325.4 °C
• PSA: 164.20000
• Density: 1.558g/cm3
• LogP: 5.12640
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 4
• Exact Mass: 576.12904013
• Heavy Atom Count: 40
• Complexity: 915

Purity/Quality:

99% ^*data from raw suppliers

Tosufloxacin Toluenesulfonate Hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1CN(CC1N)C2=C(C=C3C(=O)C(=CN(C3=N2)C4=C(C=C(C=C4)F)F)C(=O)O)F
• Description: Tosufloxacin tosylate is a new fluoroquinolone antibacterial structurally related to temafloxacin. Mechanistically, it is a microbial DNA topoisomerase inhibitor, useful against beta-lactamase producing organisms. Tosufloxacin tosylate is reported to be particularly effective against Salmonella enteritidis.
• Uses: Useful as a therapeutic antimicrobial for the treatment of respiratory infections. Useful as a therapeutic antimicrobial for the treatment of respiratory infections

Technology Process of Tosufloxacin tosylate

There total 1 articles about Tosufloxacin tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine 3-carboxylic acid ethyl ester (105152-95-2) + toluene-4-sulfonic acid (104-15-4) → 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid tosylate (100490-94-6,115964-29-9)

Guidance literature:

In ethanol; water; at 65 - 85 ℃; for 7h; Solvent; Temperature;

upstream raw materials:

7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine 3-carboxylic acid ethyl ester

toluene-4-sulfonic acid

Refernces