Multi-step reaction with 7 steps
1: caesium carbonate / 60 °C
2: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation
3: acetic acid; trifluoroacetic acid; platinum(IV) oxide; hydrogen / 36 h / 760.05 Torr
4: triethylamine / dichloromethane / 0.5 h / 20 °C
5: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation
6: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C
7: N-ethyl-N,N-diisopropylamine / ethanol / 50 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; platinum(IV) oxide; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); hydrogen; palladium diacetate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
2: |Suzuki Coupling / 5: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm400402q