Technology Process of Tolmetin glycinamide
There total 7 articles about Tolmetin glycinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water;
at 30 ℃;
for 3h;
Large scale reaction;
DOI:10.1021/op900284w
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / dichloromethane / 3 h / 30 °C
2.1: o-xylene / 24 h / 145 °C
3.1: sodium hydroxide / methanol; water / 2 h / 30 °C
4.1: triethylamine / dichloromethane / 0.83 h / 30 °C / Large scale reaction
4.2: 30 °C
5.1: sodium hydroxide / water / 3 h / 30 °C / Large scale reaction
With
potassium carbonate; triethylamine; sodium hydroxide;
In
methanol; dichloromethane; o-xylene; water;
DOI:10.1021/op900284w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: o-xylene / 24 h / 145 °C
2.1: sodium hydroxide / methanol; water / 2 h / 30 °C
3.1: triethylamine / dichloromethane / 0.83 h / 30 °C / Large scale reaction
3.2: 30 °C
4.1: sodium hydroxide / water / 3 h / 30 °C / Large scale reaction
With
triethylamine; sodium hydroxide;
In
methanol; dichloromethane; o-xylene; water;
DOI:10.1021/op900284w
