2-[2-(aminomethyl)cyclohexyl]acetic Acid

Base Information Edit

Chemical Name:2-[2-(aminomethyl)cyclohexyl]acetic Acid
CAS No.:60142-96-3
Molecular Formula:C9H17NO2
Molecular Weight:171.239
Hs Code.:29224999
NSC Number:759254
Wikidata:Q27166908
Mol file:60142-96-3.mol

Synonyms:2-[2-(aminomethyl)cyclohexyl]acetic Acid;BSPBio_002312;SPECTRUM1505805;2-(Aminomethyl)cyclohexanessig;SCHEMBL3278947;CHEBI:95126;HMS1922H12;HMS2093F06;Pharmakon1600-01505805;NSC759254;CCG-213554;NCGC00095184-01;NCGC00095184-02;NCGC00095184-03;AB01563336_01;SR-05000001804;SR-05000001804-1;Q27166908

Suppliers and Price of 2-[2-(aminomethyl)cyclohexyl]acetic Acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Gabapentin
1mg
$ 618.00

Usbiological
Gabapentin
1mg
$ 595.00

Usbiological
Gabapentin
1mg
$ 523.00

TRC
Gabapentin
1g
$ 120.00

TRC
Gabapentin
100mg
$ 105.00

TCI Chemical
Gabapentin >98.0%(GC)(T)
5g
$ 61.00

TCI Chemical
Gabapentin >98.0%(GC)(T)
25g
$ 185.00

Sigma-Aldrich
Gabapentin solid
50mg
$ 417.00

Sigma-Aldrich
Gabapentin United States Pharmacopeia (USP) Reference Standard
250mg
$ 366.00

Sigma-Aldrich
Gabapentin European Pharmacopoeia (EP) Reference Standard
$ 190.00

Total 304 raw suppliers

Chemical Property of 2-[2-(aminomethyl)cyclohexyl]acetic Acid Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:6.32E-05mmHg at 25°C
Melting Point:162 °C
Refractive Index:1.484
Boiling Point:314.4 °C at 760 mmHg
PKA:pKa1 (25°) 3.68; pKa2 10.70
Flash Point:144 °C
PSA：63.32000
Density:1.058 g/cm³
LogP:2.07060
Storage Temp.:Desiccate at +4°C
Solubility.:H2O: 10 mg/mL
Water Solubility.:H2O: 10 mg/mL
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:171.125928785
Heavy Atom Count:12
Complexity:159

Purity/Quality:

99%, ^*data from raw suppliers

Gabapentin ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xi
Hazard Codes:T,Xi,F
Statements: 61-36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 53-26-36/37/39-45-36-36/37-16

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)CC(=O)O)CN
Recommended First-Line Agent for Neuropathic Pain Gabapentin is recommended as a first-line agent for treating neuropathic pain and has proven efficacy in chronic pain conditions.
Mechanism of Action Gabapentin primarily affects pain modulation by the central nervous system (CNS), with some evidence for peripheral activity. It binds to voltage-sensitive calcium channels at the 伪2未-1 site, affecting their function and receptor trafficking. Neuroimaging studies have shown that gabapentinoids affect brain function in models of central sensitization and in patients with chronic pain.
History and Approval Gabapentin, originally developed in 1976, was approved by the FDA in 1998 for the treatment of postherpetic neuralgia (PHN) and diabetic peripheral neuropathy (DPN). It was not metabolized hepatically and was not bound to plasma proteins. Gabapentinoid use has significantly increased since FDA approval, with gabapentin use tripling in the USA between 2002 and 2015.
Use in Chronic Pain Management Gabapentin has been increasingly used off-label for chronic pelvic pain due to its efficacy in other chronic pain conditions. It has been shown to inhibit astrocyte-derived thrombospondins (TSPs), which play a major role in chronic pain after neuronal injury. Gabapentin inhibits TSPs via 伪2未-1 to block synaptogenesis, leading to analgesia.
Pharmacological Characteristics Gabapentin's unique pharmacologic characteristics include its binding to voltage-sensitive calcium channels at the 伪2未-1 site. Through these mechanisms, gabapentin influences GABA and glutamate tone/activity, which can be clinically measured.
Additional Uses Gabapentin is efficacious for the treatment of acute alcohol withdrawal symptoms and provides short-term relapse prevention after medicated alcohol detoxification, possibly by normalizing sleep.

Technology Process of 2-[2-(aminomethyl)cyclohexyl]acetic Acid

There total 55 articles about 2-[2-(aminomethyl)cyclohexyl]acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%