DIBENZOFURAN-2-CARBOXALDEHYDE

Base Information

• Chemical Name: DIBENZOFURAN-2-CARBOXALDEHYDE
• CAS No.: 5397-82-0
• Molecular Formula: C13H8O2
• Molecular Weight: 196.205
• Hs Code.: 2932999099
• Mol file: 5397-82-0.mol

Synonyms:NSC 4270;

Chemical Property of DIBENZOFURAN-2-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 2.21E-05mmHg at 25°C
• Melting Point: 74 °C
• Refractive Index: 1.734
• Boiling Point: 360.5 °C at 760 mmHg
• Flash Point: 170.2 °C
• PSA: 30.21000
• Density: 1.289 g/cm³
• LogP: 3.39850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

99.5% ^*data from raw suppliers

Dibenzo[b,d]furan-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as an pharmaceutical intermediate.

Technology Process of DIBENZOFURAN-2-CARBOXALDEHYDE

There total 13 articles about DIBENZOFURAN-2-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-iodo-1,5-dimethyl-3-phenoxybenzene → dibenzofuran-2-carbaldehyde (5397-82-0)

Guidance literature:

With palladium 10% on activated carbon; sodium acetate; In N,N-dimethyl acetamide; at 140 ℃; for 16h;

DOI:10.1021/acs.joc.5b00634

Reference yield: 88.0%

2-hydroxymethyl-dibenzo[b,d]furan (86607-82-1) → dibenzofuran-2-carbaldehyde (5397-82-0)

Guidance literature:

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); oxygen; In toluene; at 110 ℃; for 24h; under 760.051 Torr; Molecular sieve; Sealed tube;

DOI:10.1002/chem.201601800

Reference yield: 85.0%

dibenzofuran (132-64-9,214827-48-2) + Dichloromethyl methyl ether (4885-02-3) → dibenzofuran-2-carbaldehyde (5397-82-0)

Guidance literature:

With tin(IV) chloride; In dichloromethane;

DOI:10.1007/s11164-016-2698-1

upstream raw materials:

dibenzofuran

hydrogen cyanide

dibenzofuran-2-carboxylic acid-(N-methyl-anilide)

dichloromethyl n-butyl ether

Downstream raw materials:

2-methyldibenzofuran

2-(2,2-diethoxyethyliminomethyl)-dibenzofuran

N-benzylamino-(dibenzofuranyl)-acetonitrile

2-hydroxydibenzofuran

Refernces

• 1、 -. "Functional material based on stable chemical structure". Paragraph 0291; 0304; 306. . Retrieved 2021/08/25.
• 2、 Liu, Haidong,Ge, Liang,Wang, Ding-Xing,Chen, Nan,Feng, Chao. "Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes". supporting information. p. 3918 - 3922. Retrieved 2019/02/19.