Technology Process of C13H15NO
There total 11 articles about C13H15NO which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
2.2: -78 - 20 °C
3.1: triethylamine / dmap / dichloromethane / 0 - 20 °C
4.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere
5.1: ethyl acetate; cyclohexane / Resolution of diastereoisomeric mixture
6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
7.1: DAICEL AS-H / isopropyl alcohol; hexane; ethanol / Resolution of racemate
With
boron trifluoride diethyl etherate; potassium tert-butylate; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid;
dmap;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; ethyl acetate; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: copper(I) bromide; lithium bromide / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 50 °C
2.2: pH 1
3.1: potassium hydroxide; sodium tetrahydroborate / water / 10 - 20 °C
4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
5.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
5.2: -78 - 20 °C
6.1: triethylamine / dmap / dichloromethane / 0 - 20 °C
7.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere
8.1: ethyl acetate; cyclohexane / Resolution of diastereoisomeric mixture
9.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
10.1: DAICEL AS-H / isopropyl alcohol; hexane; ethanol / Resolution of racemate
With
sodium tetrahydroborate; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; potassium tert-butylate; water; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; potassium hydroxide; copper(I) bromide; lithium bromide;
dmap;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; water; ethyl acetate; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C
1.2: -78 - 20 °C
2.1: triethylamine / dmap / dichloromethane / 0 - 20 °C
3.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere
4.1: ethyl acetate; cyclohexane / Resolution of diastereoisomeric mixture
5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C
6.1: DAICEL AS-H / isopropyl alcohol; hexane; ethanol / Resolution of racemate
With
boron trifluoride diethyl etherate; potassium tert-butylate; diisobutylaluminium hydride; triethylamine;
dmap;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; ethyl acetate; isopropyl alcohol; acetonitrile;
