ALPHA-HYDROXYBENZYLPHOSPHINIC ACID SODIU

Base Information

• Chemical Name: ALPHA-HYDROXYBENZYLPHOSPHINIC ACID SODIU
• CAS No.: 7492-18-4
• Molecular Formula: C8H9NaO3P
• Molecular Weight: 194.102
• Mol file: 7492-18-4.mol

Synonyms:Phosphinic acid, (hydroxyphenylmethyl)-, monosodium salt;Phosphinic acid, (α-hydroxybenzyl)-, monosodium salt;sodium α-hydroxybenzylphosphinate;Sodium alpha-hydroxybenzylphosphinate;

Chemical Property of ALPHA-HYDROXYBENZYLPHOSPHINIC ACID SODIU

Chemical Property:

• PSA: 83.83000
• LogP: 1.58270

Purity/Quality:

99.9% ^*data from raw suppliers

α-HydroxybenzylphosphinicAcidSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: The Na salt of α-hydroxybenzylphosphinic acid (Phos) is a prototype. It is harmless. Like insulin, it promotes the formation of glycogen in the isolated rat diaphragm in oxygenated glucose-Ringer solution and decreases the breakdown of glycogen provoked by adrenaline in the diaphragm preparation.

Technology Process of ALPHA-HYDROXYBENZYLPHOSPHINIC ACID SODIU

There total 2 articles about ALPHA-HYDROXYBENZYLPHOSPHINIC ACID SODIU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

O-trimethylsilyl [phenyl(trimethylsiloxy)methyl]phosphonite (56547-85-4) → [hydroxy(phenyl)methyl]phosphinate sodium salt (7492-18-4)

Guidance literature:

With methanol; sodium methylate; In diethyl ether; Heating;

DOI:10.1002/hc.20430

Reference yield: 85.0%

benzaldehyde (100-52-7) → [hydroxy(phenyl)methyl]phosphinate sodium salt (7492-18-4)

Guidance literature:

With sodium phosphate; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

upstream raw materials:

O-trimethylsilyl [phenyl(trimethylsiloxy)methyl]phosphonite

benzaldehyde

Refernces

• 1、 Dussart, Jade,Deschamp, Julia,Monteil, Maelle,Gager, Olivier,Migianu-Griffoni, Evelyne,Lecouvey, Marc. "A General Protocol for the Synthesis of H-α-Hydroxyphosphinates". . p. 421 - 432. Retrieved 2019/01/10.