dimethyl 1-diazo-2-phenylethylphosphonate

Base Information

• Chemical Name: dimethyl 1-diazo-2-phenylethylphosphonate
• CAS No.: 51463-49-1
• Molecular Formula: C₁₀H₁₃N₂O₃P
• Molecular Weight: 240.199
• Mol file: 51463-49-1.mol

Synonyms:dimethyl 1-diazo-2-phenylethylphosphonate

Chemical Property of dimethyl 1-diazo-2-phenylethylphosphonate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl 1-diazo-2-phenylethylphosphonate

There total 2 articles about dimethyl 1-diazo-2-phenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl bromide (100-39-0) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → dimethyl 1-diazo-2-phenylethylphosphonate (51463-49-1)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 0.25h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c4cc05684a

Reference yield:

C17H21N2O5PS → dimethyl 1-diazo-2-phenylethylphosphonate (51463-49-1)

Guidance literature:

With potassium carbonate;

Reference yield: 98.0%

dimethyl 1-diazo-2-phenylethylphosphonate (51463-49-1) → (E)-styrylphosphonic acid dimethyl ester (60190-89-8)

Guidance literature:

With copper; In toluene; for 0.333333h; Reagent/catalyst; Solvent; Temperature; stereoselective reaction; Reflux; Inert atmosphere;

DOI:10.1039/c4cc05684a

upstream raw materials:

benzyl bromide

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

Downstream raw materials:

(E)-styrylphosphonic acid dimethyl ester

1-phenylvinylphosphonic acid dimethyl ester

dimethyl 2-phenylethenylphosphonate

3-benzyl-1H-indazole

Refernces