Carubicin

Base Information

• Chemical Name: Carubicin
• CAS No.: 52794-97-5
• Molecular Formula: C26H28ClNO10
• Molecular Weight: 549.96
• Mol file: 52794-97-5.mol

Synonyms:Carminomycin hydrochloride;Caminomycin hydrochloride;

Chemical Property of Carubicin

Chemical Property:

• Vapor Pressure: 1.14E-23mmHg at 25°C
• Boiling Point: 750.6°Cat760mmHg
• PKA: pKa1 8.00; pKa2 10.16(at 25℃)
• Flash Point: 407.7°C
• PSA: 196.84000
• Density: 1.63g/cm³
• LogP: 2.22820

Purity/Quality:

99%+, ^*data from raw suppliers

KarminomycinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antineoplastic. . Karminomycin Hydrochloride is an antibiotic that potently kills human tumor cells and their multidrug resistant variants. Highly active quinone-containing anticancer drugs. A new anthracycline antineoplastic antibiotic.

Technology Process of Carubicin

There total 1 articles about Carubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ carminomycin I hydrochloride (52794-97-5)

Guidance literature:

Reference yield: 72.0%

carminomycin I hydrochloride (52794-97-5) + trifluoroacetic anhydride (407-25-0) → 4-demethyl-3'-trifluoroacetamido-daunorubicine (68594-06-9)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 0.166667h;

Reference yield:

carminomycin I hydrochloride (52794-97-5) → C26H19BO7 (286010-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 24 mg / aq. HCl / 0.75 h / 90 °C

2.1: 98 percent / p-TsOH / CH₂Cl₂ / 16 h / 20 °C

3.1: dichloroacetic acid; H₂ / Adams catalyst / ethyl acetate / 2 h / 20 °C

3.2: 98 percent / air; sat. aq. NaHCO₃ / tetrahydrofuran

With hydrogenchloride; dichloro-acetic acid; hydrogen; toluene-4-sulfonic acid; platinum(IV) oxide; In dichloromethane; ethyl acetate; 1.1: Hydrolysis / 2.1: Esterification / 3.1: Catalytic hydrogenation / 3.2: Oxidation;

DOI:10.1071/ch99151

Downstream raw materials:

cis-9-acetyl-4-hydroxy-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-5,12-naphthacenedione

4-demethyl-3'-trifluoroacetamido-daunorubicine

C₂₆H₁₉BO₇

C₂₆H₁₉BO₈

Refernces

• 1、 -. "Antibiotic complex". . . Retrieved 2008/06/13.