Technology Process of (2S)-2-[5-(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)pentanamido]pentanedioic acid
There total 15 articles about (2S)-2-[5-(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)pentanamido]pentanedioic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 60 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 6 h
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 30 °C
4: triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 25 °C
With
dmap; lithium hydroxide monohydrate; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00308
- Guidance literature:
-
Multi-step reaction with 9 steps
1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide
2: hydrogen; rhodium contaminated with carbon / ethyl acetate
3: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C
4: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 °C
5: potassium carbonate / N,N-dimethyl-formamide / 60 °C
6: lithium hydroxide monohydrate; water / tetrahydrofuran / 6 h
7: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 30 °C
8: triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
9: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / 25 °C
With
dmap; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; lithium hydroxide monohydrate; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308