N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide

Base Information

• Chemical Name: N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide
• CAS No.: 952664-71-0
• Molecular Formula: C₁₆H₁₉FN₂O₃
• Molecular Weight: 306.337
• Mol file: 952664-71-0.mol

Synonyms:N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide

Chemical Property of N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide

There total 3 articles about N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitroaniline (952664-70-9) + butyryl chloride (141-75-3) → N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide (952664-71-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

3-fluoro-4-nitroaniline (2369-13-3) → N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide (952664-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform; acetic acid

2: CuI; triethylamine / Pd(PPh₃)2Cl₂ / water; toluene

3: triethylamine / dichloromethane

With CuI; bromine; triethylamine; Pd(PPh₃)2Cl₂; In dichloromethane; chloroform; water; acetic acid; toluene;

Reference yield:

2-bromo-5-fluoro-4-nitroaniline (952664-69-6) → N-(2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitrophenyl)butyramide (952664-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; triethylamine / Pd(PPh₃)2Cl₂ / water; toluene

2: triethylamine / dichloromethane

With CuI; triethylamine; Pd(PPh₃)2Cl₂; In dichloromethane; water; toluene;

upstream raw materials:

2-(3,3-dimethylbut-1-ynyl)-5-fluoro-4-nitroaniline

butyryl chloride

3-fluoro-4-nitroaniline

2-bromo-5-fluoro-4-nitroaniline

Downstream raw materials:

6-tert-butoxy-2-tert-butyl-5-nitro-1H-indole

2-tert-butyl-6-fluoro-5-nitro-1H-indole

Refernces

• 1、 -. "COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES". . . Retrieved 2012/04/23.