Lonafarnib

Base Information Edit

Chemical Name:Lonafarnib
CAS No.:193275-84-2
Molecular Formula:C27H31Br2ClN4O2
Molecular Weight:638.83
Hs Code.:
European Community (EC) Number:679-527-9
NSC Number:719467
UNII:IOW153004F
DSSTox Substance ID:DTXSID90172927
Nikkaji Number:J1.013.643A
Wikipedia:Lonafarnib
Wikidata:Q3258910
NCI Thesaurus Code:C1829
RXCUI:2467553
Pharos Ligand ID:B4VX44PMPXKJ
Metabolomics Workbench ID:130085
ChEMBL ID:CHEMBL298734
Mol file:193275-84-2.mol

Synonyms:(+)4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide;1-piperidinecarboxamide, 4(2-(4-(11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine-11-yl)-1-piperidinyl)-2-oxoethyl)-;4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide;lonafarnib;Sarasar;SCH 66336;SCH-66336;SCH66336;zokinvy

Suppliers and Price of Lonafarnib

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Lonafarnib
1mg
$ 50.00

TRC
Lonafarnib
50mg
$ 375.00

Tocris
Lonafarnib ≥98%(HPLC)
10
$ 135.00

Tocris
Lonafarnib ≥98%(HPLC)
50
$ 563.00

DC Chemicals
Lonafarnib >98%
1 g
$ 2900.00

DC Chemicals
Lonafarnib >98%
250 mg
$ 1500.00

CSNpharm
Lonafarnib
5mg
$ 68.00

CSNpharm
Lonafarnib
10mg
$ 116.00

ChemScene
Lonafarnib 98.67%
5mg
$ 146.00

ChemScene
Lonafarnib 98.67%
10mg
$ 264.00

Total 64 raw suppliers

Chemical Property of Lonafarnib Edit

Chemical Property:

Melting Point:214.5-215.9° (monohydrate); mp 222-223°
Boiling Point:710.432 °C at 760 mmHg
PKA:15.76±0.40(Predicted)
Flash Point:383.455 °C
PSA：79.53000
Density:1.537 g/cm³
LogP:6.48600
Storage Temp.:-20°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:638.04818
Heavy Atom Count:36
Complexity:790

Purity/Quality:

98%,99%, ^*data from raw suppliers

Lonafarnib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Genetic Disease Agents, Small Molecule Enzyme Inhibitors
Canonical SMILES:C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
Isomeric SMILES:C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N
Recent ClinicalTrials:Once Daily Dosing of Lonafarnib Co-administered With Ritonavir for Treatment of Chronic Hepatitis D Virus Infection
Recent EU Clinical Trials:A Phase 3, Matrix Design, Partially Double-Blind, Randomized Study of the Efficacy and Safety of 50 mg Lonafarnib/100 mg Ritonavir BID with and without 180 mcg PEG IFN-alfa-2a for 48 Weeks Compared with PEG IFN-alfa-2a Monotherapy and Placebo Treatment in Patients Chronically Infected with Hepatitis Delta Virus Being Maintained on Anti-HBV Nucleos(t)ide Therapy (D-LIVR)
Uses Chemotherapeutic (farnesyl transfer ase inhibitor). Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells

Technology Process of Lonafarnib

There total 16 articles about Lonafarnib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%