DELTA-8-THC

Base Information

• Chemical Name: DELTA-8-THC
• CAS No.: 5957-75-5
• Molecular Formula: C21H30 O2
• Molecular Weight: 314.468
• NSC Number: 134453
• Nikkaji Number: J280.521I
• Wikipedia: Delta-8-Tetrahydrocannabinol
• NCI Thesaurus Code: C61312
• ChEMBL ID: CHEMBL46518
• Mol file: 5957-75-5.mol

Synonyms:6H-Dibenzo[b,d]pyran-1-ol,6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-;6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-,trans-(-)- (8CI); (-)-trans-D8-Tetrahydrocannabinol; (-)-D6-Tetrahydrocannabinol; (-)-D8-6a,10a-trans-Tetrahydrocannabinol; (-)-D8-THC; (-)-D8-Tetrahydrocannabinol; (-)-D8-trans-Tetrahydrocannabinol;Cannabinol, D1(6)-tetrahydro-;NSC 134453; l-D8-Tetrahydrocannabinol;trans-D8-Tetrahydrocannabinol; D1(6)-Tetrahydrocannabinol; D1(6)-trans-Tetrahydrocannabinol; D6-Tetrahydrocannabinol; D8-THC; D8-Tetrahydrocannabinol; D8-l-Tetrahydrocannabinol; D8-trans-Tetrahydrocannabinol

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of DELTA-8-THC

Chemical Property:

• Vapor Pressure: 1.98E-06mmHg at 25°C
• Refractive Index: 1.5404 (estimate)
• Boiling Point: 383.5 °C at 760 mmHg
• PKA: 9.83±0.60(Predicted)
• Flash Point: 144.5 °C
• PSA: 29.46000
• Density: 1.015 g/cm³
• LogP: 5.73580
• Storage Temp.: −20°C
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 314.224580195
• Heavy Atom Count: 23
• Complexity: 439

Purity/Quality:

Safty Information:

• Pictogram(s): F
• Hazard Codes: F,T
• Statements: 11-39/23/24/25-23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC1=CC(=C2C3CC(=CCC3C(OC2=C1)(C)C)C)O
• Recent ClinicalTrials: Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
• Uses: It is one of the active constituent of cannabis. Agonist at CB1 and CB2 cannabinoid receptors. Antiemetic; appetite stimulant. Controlled substance (hallucinogen).

Technology Process of DELTA-8-THC

There total 16 articles about DELTA-8-THC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(-)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol (13956-30-4,521-37-9) → delta-8-tetrahydrocannabinol (5957-75-5) + dronabinol (1972-08-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 96h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1021/acs.jnatprod.0c00436

Reference yield: 85.0%

CBD (13956-29-1,521-37-9) → delta-8-tetrahydrocannabinol (5957-75-5) + dronabinol (1972-08-3)

Guidance literature:

With Amberlyst-15; In n-heptane; for 1h; Reagent/catalyst; Solvent; Reflux;

Reference yield: 66.0%

(-)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol (13956-30-4,521-37-9) → delta-8-tetrahydrocannabinol (5957-75-5) + dronabinol (1972-08-3) + (-)-(2R,5R,6R)-5-Isopropenyl-2-methyl-9-pentyl-3,4,5,6-tetrahydro-2,6-methano-2H-1-benzoxocan-7-ol

Guidance literature:

With toluene-4-sulfonic acid; In hexane; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1021/acs.jnatprod.0c00436

upstream raw materials:

(6aR,9S,10aR)-9α-bromo-6a,10a-trans-hexahydrocannabinol

(1S,2S,3R,6R)-(+)-trans-car-2-ene epoxide

Olivetol

p‐mentha‐1,5‐dien‐8‐ol

Downstream raw materials:

(-)-O-methyl-Δ⁸-tetrahydrocannabinol

3'-hydroxy-Δ8-tetrahydrocannabinol

7beta-Hydroxy-D₈-tetrahydrocannabinol

11-hydroxy-Δ8-tetrahydrocannabinol

Refernces

• 1、 -. "METHODS FOR CONVERTING CBD TO TETRAHYDROCANNABINOLS". Paragraph 0081. . Retrieved 2021/07/24.
• 2、 -. "Conversion of cannabidiol or delta-9 tetrahydrocannabinolic acid to delta-9 tetrahydrocannabinol and delta-8 tetrahydrocannabinol in nontoxic heterogeneous mixtures". Paragraph 5-8. . Retrieved 2021/03/11.