1-(cyclobutylthio)-4-fluorobenzene

Base Information

• Chemical Name: 1-(cyclobutylthio)-4-fluorobenzene
• CAS No.: 871657-76-0
• Molecular Formula: C₁₀H₁₁FS
• Molecular Weight: 182.262
• Mol file: 871657-76-0.mol

Synonyms:1-(cyclobutylthio)-4-fluorobenzene

Chemical Property of 1-(cyclobutylthio)-4-fluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(cyclobutylthio)-4-fluorobenzene

There total 1 articles about 1-(cyclobutylthio)-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorothiophenol (371-42-6) + Bromocyclobutane (4399-47-7) → 1-(cyclobutylthio)-4-fluorobenzene (871657-76-0)

Guidance literature:

4-Fluorothiophenol; With sodium t-butanolate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

Bromocyclobutane; In dimethyl sulfoxide; at 80 ℃;

DOI:10.1002/anie.201711828

Reference yield:

1-(cyclobutylthio)-4-fluorobenzene (871657-76-0) → 1-(cyclobutylsulfonyl)-p-fluorobenzene (871657-74-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201711828

Reference yield:

1-(cyclobutylthio)-4-fluorobenzene (871657-76-0) → (1-(4-(cyclobutylsulfonyl)phenyl)azetidin-3-yl)methyl methanesulfonate

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 80 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/anie.201711828

upstream raw materials:

4-Fluorothiophenol

Bromocyclobutane

Downstream raw materials:

1-(cyclobutylsulfonyl)-p-fluorobenzene

Refernces

• 1、 Aguilar, Angelo,Zheng, Ke,Xu, Tianfeng,Xu, Shilin,Huang, Liyue,Fernandez-Salas, Ester,Liu, Liu,Bernard, Denzil,Harvey, Kaitlin P.,Foster, Caroline,McEachern, Donna,Stuckey, Jeanne,Chinnaswamy, Krishnapriya,Delproposto, James,Kampf, Jeff W.,Wang, Shaomeng. "Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction". . p. 6015 - 6034. Retrieved 2019/07/03.