Technology Process of -(S)-alanyl>-(S)-pyroglutamic acid tert-butyl ester
There total 6 articles about -(S)-alanyl>-(S)-pyroglutamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / HCl / 2 h / Heating
2: NaOH, H2 / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr
3: DCC / 1,2-dimethoxy-ethane; CHCl3 / 25 °C
4: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight
With
hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1021/jm00149a009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaOH, H2 / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr
2: DCC / 1,2-dimethoxy-ethane; CHCl3 / 25 °C
3: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight
With
sodium hydroxide; hydrogen; sodium hydride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1021/jm00149a009
- Guidance literature:
-
Multi-step reaction with 2 steps
1: DCC / 1,2-dimethoxy-ethane; CHCl3 / 25 °C
2: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight
With
sodium hydride; dicyclohexyl-carbodiimide;
In
1,2-dimethoxyethane; chloroform;
DOI:10.1021/jm00149a009
