1,7-DIDEAZAADENINE

Base Information

• Chemical Name: 1,7-DIDEAZAADENINE
• CAS No.: 74420-00-1
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 29339900
• Mol file: 74420-00-1.mol

Synonyms:1,7-Dideazaadenine;4-Amino-1H-pyrrolo[2,3-b]pyridine;4-Amino-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of 1,7-DIDEAZAADENINE

Chemical Property:

• Refractive Index: 1.78
• Boiling Point: 348.6±35.0 °C(Predicted)
• PKA: 8.28±0.20(Predicted)
• Density: 1.367 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1,7-Dideazaadenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-Pyrrolo[2,3-b]pyridin-4-amine is used in the preparation of pyrrolotriazines.

Technology Process of 1,7-DIDEAZAADENINE

There total 1 articles about 1,7-DIDEAZAADENINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-7-azaindole (55052-28-3) → 4-amino-1H-pyrrolo<2,3-b>pyridine (74420-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tert-butoxide; Pd(OAc)2; (o-biphenyl)P(cyclohexyl)2 / dioxane / 16 h / 100 °C

2: 13.15 g / methanesulfonic acid / Pd/C / ethanol / 72 h / 105 °C

With palladium diacetate; methanesulfonic acid; sodium t-butanolate; CyJohnPhos; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1021/ol036030z

Reference yield: 64.0%

4-amino-1H-pyrrolo<2,3-b>pyridine (74420-00-1) → 4-chloro-7-azaindole (55052-28-3)

Guidance literature:

4-amino-1H-pyrrolo<2,3-b>pyridine; With sulfuric acid; isopentyl nitrite; In acetic acid; at 12 ℃; for 3h;

With hydrogenchloride; copper(l) chloride; In water; acetic acid; at 50 - 90 ℃; for 0.5h;

With sodium hydroxide; In water; acetic acid; pH=> 7; Product distribution / selectivity;

Reference yield: 44.0%

4-amino-1H-pyrrolo<2,3-b>pyridine (74420-00-1) → 1H-pyrrolo<2,3-b>pyridin-4-ol (1,7-Dideazahypoxanthine) (74420-02-3) + 4-fluoro-1H-pyrrolo[2,3-b]pyridine (640735-23-5)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; In water; at 0 - 20 ℃; for 22h;

DOI:10.1021/ol036030z

upstream raw materials:

4-chloro-7-azaindole

Downstream raw materials:

1-benzyl-1H-pyrrolo[2,3-b]pyridin-4-amine

1H-pyrrolo<2,3-b>pyridin-4-ol (1,7-Dideazahypoxanthine)

4-fluoro-1H-pyrrolo[2,3-b]pyridine

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide

Refernces