(4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate

Base Information

• Chemical Name: (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate
• CAS No.: 1598371-34-6
• Molecular Formula: CF₃O₃S*C₃₀H₃₄NO₃S
• Molecular Weight: 637.741
• Mol file: 1598371-34-6.mol

Synonyms:(4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate

Chemical Property of (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate

There total 6 articles about (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trifluorormethanesulfonic acid (1493-13-6) + 4-(4-(4-(phenylthio)benzoyl)piperidin-1-yl)butyl acetate (1598371-59-5) + Diphenyliodonium triflate (66003-76-7) → (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate (1598371-34-6)

Guidance literature:

With copper(II) benzoate; In chlorobenzene; at 125 ℃; for 1h; Inert atmosphere;

Reference yield:

4-(4-(4-(phenylthio)benzoyl)piperidin-1-yl)butyl acetate (1598371-59-5) + Diphenyliodonium triflate (66003-76-7) → (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate (1598371-34-6)

Guidance literature:

With copper(II) benzoate monohydrate; trifluorormethanesulfonic acid; In chlorobenzene; at 125 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b00652

Reference yield:

phenyl(4-bromophenyl)sulfide (65662-88-6) → (4-(1-(4-acetoxybutyl)piperidine-4-carbonyl)phenyl)diphenylsulfonium trifluoromethanesulfonate (1598371-34-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 0 °C

2.1: hydrogenchloride / tetrahydrofuran / 12 h / 20 °C

3.1: potassium carbonate / acetone / 12 h / 20 - 60 °C

4.1: trifluorormethanesulfonic acid; copper(II) benzoate monohydrate / chlorobenzene / 1 h / 125 °C

With hydrogenchloride; n-butyllithium; copper(II) benzoate monohydrate; trifluorormethanesulfonic acid; potassium carbonate; In tetrahydrofuran; chlorobenzene; acetone;

DOI:10.1021/acs.jmedchem.5b00652

upstream raw materials:

trifluorormethanesulfonic acid

4-(4-(4-(phenylthio)benzoyl)piperidin-1-yl)butyl acetate

Diphenyliodonium triflate

phenyl(4-bromophenyl)sulfide

Downstream raw materials:

C₁₈H₂₄⁽¹⁸⁾FNO₃

[¹⁸F](4-fluorophenyl)(1-(4-hydroxybutyl)piperidin-4-yl)methanone

Refernces

• 1、 -. "COMPOUNDS AND THEIR SYNTHESIS". Page/Page column 34. . Retrieved 2014/05/07.