Technology Process of 17β-hydroxy-7α-methylene-5α-oxo-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
There total 1 articles about 17β-hydroxy-7α-methylene-5α-oxo-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(I) iodide-lithium chloride; boron trifluoride diethyl etherate / tetrahydrofuran
2: potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate / tetrahydrofuran; methanol; water / 14 h / 20 - 50 °C
With
potassium fluoride; copper(I) iodide-lithium chloride; boron trifluoride diethyl etherate; dihydrogen peroxide; potassium hydrogencarbonate;
In
tetrahydrofuran; methanol; water;
1: Michael conjugate addition, 1,6- / 2: Tamao oxidation;
DOI:10.1016/j.steroids.2010.08.009
