(S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid

Base Information

• Chemical Name: (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid
• CAS No.: 1403506-14-8
• Molecular Formula: CH₄O₃S*C₂₈H₃₄ClN₅O₇S
• Molecular Weight: 716.233
• Mol file: 1403506-14-8.mol

Synonyms:(S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid

Chemical Property of (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid

There total 10 articles about (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + PL-225B (1403506-13-7) → (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid (1403506-14-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

4-Chloro-2-nitroaniline (89-63-4) → (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid (1403506-14-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale

1.2: 0.5 h / -5 - 0 °C

2.1: Polyphosphoric acid (PPA) / 110 °C

3.1: acetic anhydride; sulfuric acid / 0 - 20 °C

3.2: 0 - 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C

5.1: triethylamine / dichloromethane / 4 h

6.1: ammonium chloride; iron / ethanol / 80 - 85 °C

7.1: dichloromethane / 20 h / 20 °C

7.2: 0.17 h

7.3: 1.5 h

8.1: tetrahydrofuran / 1.5 h / 20 °C

With oxalyl dichloride; sulfuric acid; acetic anhydride; iron; ammonium chloride; triethylamine; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

(R)-phenyl glycidyl ether (71031-03-3,71031-02-2) → (S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid (1403506-14-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C

1.2: 15 h / 45 - 50 °C

2.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice

3.1: triethylamine / dichloromethane / 4 h

4.1: ammonium chloride; iron / ethanol / 80 - 85 °C

5.1: dichloromethane / 20 h / 20 °C

5.2: 0.17 h

5.3: 1.5 h

6.1: tetrahydrofuran / 1.5 h / 20 °C

With ammonium formate; iron; ammonium chloride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

(R)-phenyl glycidyl ether

methanesulfonic acid

PL-225B

4-Chloro-2-nitroaniline

Refernces