Technology Process of N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-1,3-thiazole-2-carboximidamide
There total 5 articles about N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-1,3-thiazole-2-carboximidamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline;
With
trimethylaluminum;
In
toluene;
at 25 ℃;
for 3.5h;
Inert atmosphere;
Cooling with ice;
thiazole-2-carbonitrile;
In
toluene;
at 80 ℃;
for 17h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/ml400519h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid; sodium bromide; acetic acid / 3 h / 85 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C
3.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere
4.1: trimethylaluminum / toluene / 3.5 h / 25 °C / Inert atmosphere; Cooling with ice
4.2: 17 h / 80 °C / Inert atmosphere; Microwave irradiation
With
sulfuric acid; trimethylaluminum; iron; potassium carbonate; acetic acid; sodium bromide;
In
N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400519h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere
2.1: trimethylaluminum / toluene / 3.5 h / 25 °C / Inert atmosphere; Cooling with ice
2.2: 17 h / 80 °C / Inert atmosphere; Microwave irradiation
With
trimethylaluminum; iron; acetic acid;
In
toluene;
DOI:10.1021/ml400519h
