VIP

Base Information

• Chemical Name: VIP
• CAS No.: 40077-57-4
• Molecular Formula: C147H238N44O42S
• Molecular Weight: 3325.80
• Mol file: 40077-57-4.mol

Synonyms:Vasoactiveintestinal octacosapeptide (pig);Dog VIP octacosapeptide;Human VIP;Human VIP (1-28);L-Aspartamide, L-histidyl-L-seryl-L-a-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-a-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-;Mouse VIP;Pig VIP;Pig vasoactive intestinal peptide;Porcine VIP;Porcinevasoactive intestinal peptide;Rat VIP;Rat vasoactive intestinal polypeptide;Sheep VIP;VIP (human);Vasoactive intestinal octacosapeptide (cattle);Vasoactive intestinaloctacosapeptide (goat);Vasoactiveintestinal octacosapeptide (rabbit);Vasoactive intestinal peptide (mouse);Vasoactive intestinal peptide (pig);Vasoactive intestinal peptide (porcine);Vasoactive intestinal polypeptide (human);Vasoactive intestinal polypeptide(rat);VIP, human, ovine, porcine, rat;VIP, human, porcine, rat: VIP (28 amino acids);

Chemical Property of VIP

Chemical Property:

• Appearance/Colour: powder
• PSA: 1478.99000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 4.02270
• Storage Temp.: −20°C
• Solubility.: 1% acetic acid: soluble 0.1%, clear, colorless

Purity/Quality:

99% ^*data from raw suppliers

Vasoactive Intestinal Peptide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Biological functions: VIP is extensively distributed in central and peripheral tissues, where it acts as a neurotransmitter and neuromodulator.8 The main activity of VIP is vasodilatation. VIP induces the dilation of vessels, which results in increased blood flow, decreased peripheral vascular resistance, and hypotension. While VIP has a suppressive effect on the intestinal smooth muscle, it exerts relaxant effects on the lower esophageal sphincter, the sphincter of Oddi, the anal sphincter, and the bronchial smooth muscle. In the small intestine, VIP facilitates the secretion of electrolytes and aqueous liquid. In the stomach, it inhibits gastric secretion. In the pancreas, VIP facilitates the external secretion of bicarbonic acid and aqueous liquid from pancreatic epithelial cells, and facilitates enzyme secretion from acinar cells. VIP promotes the secretion of both insulin and glucagon in a glucose-dependent manner. VIP is broadly distributed in the central nervous system, especially in the hypothalamus and pituitary anterior lobe, and is associated with the regulation of pituitary hormones. VIP is produced by lymphoid tissue and exerts a wide spectrum of immunological functions, controlling the homeostasis of the immune system through different receptors expressed in various immunocompetent cells.?VIP acts as a growth factor. It functions as a proliferative factor in normal tissue cells as well as in cancer cells. VIP might inhibit apoptosis by stimulating the expression of the apoptosis-inhibiting gene Bcl2 or by inhibiting the activity of caspase 3.
• Uses: Pulmonary hypertension;Erectile dysfunction Vasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.
• Clinical Use: 28-peptide that is structurally related to secretin and glucagon. It has a diverse biological actions. It has orphan drug status for the treatment of acute esophageal food impaction. Several clinical trials have been reported regarding the use of VIP or its analog for asthma and sarcoidosis. In an open clinical Phase II study, patients with histologically proven sarcoidosis and active disease were treated with nebulized VIP. VIP inhalation was safe and well tolerated, and significantly reduced the production of tumor necrosis factor-α by cells isolated from the bronchoalveolar lavage fluids of these patients.