2,5-DIMETHYL-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 2,5-DIMETHYL-1H-BENZIMIDAZOLE
• CAS No.: 1792-41-2
• Molecular Formula: C9H10N2
• Molecular Weight: 146.192
• Hs Code.: 2933990090
• Mol file: 1792-41-2.mol

Synonyms:1H-Benzimidazole,2,5-dimethyl- (9CI);Benzimidazole, 2,5(or 2,6)-dimethyl- (7CI);Benzimidazole,2,5-dimethyl- (8CI);2,5-Dimethyl-1H-benzimidazole;2,5-Dimethylbenzimidazole;2,6-Dimethylbenzimidazole;NSC 38553;

Chemical Property of 2,5-DIMETHYL-1H-BENZIMIDAZOLE

Chemical Property:

• Appearance/Colour: light brown powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 202-205 °C
• Refractive Index: 1.645
• Boiling Point: 350.003 °C at 760 mmHg
• Flash Point: 186.614 °C
• PSA: 28.68000
• Density: 1.145 g/cm³
• LogP: 2.17970

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dimethyl-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DIMETHYL-1H-BENZIMIDAZOLE

There total 13 articles about 2,5-DIMETHYL-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(4-nitrophenyl)isoxazol-5(4H)-one (39214-83-0) + 4-methyl-1,2-diaminobenzene (496-72-0) → 2,5-dimethylbenzimidazole (1792-41-2) + 7-Methyl-4-(4-nitro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (142335-32-8)

Guidance literature:

In acetic acid; at 90 ℃;

DOI:10.1055/s-1992-26130

Reference yield: 80.0%

3-phenyl-4H-isoxazol-5-one (1076-59-1) + 4-methyl-1,2-diaminobenzene (496-72-0) → 2,5-dimethylbenzimidazole (1792-41-2) + 4-methyl 7-phenyl 1,5-benzodiazepin 2-one (64376-02-9)

Guidance literature:

In acetic acid; at 90 ℃;

DOI:10.1055/s-1992-26130

Reference yield: 74.0%

4-methyl-1,2-diaminobenzene (496-72-0) + 3-(4-chlorophenyl)isoxazol-5-(4H)-one (25755-85-5) → 2,5-dimethylbenzimidazole (1792-41-2) + 4-(4-Chloro-phenyl)-7-methyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (142335-31-7)

Guidance literature:

In acetic acid; at 90 ℃;

DOI:10.1055/s-1992-26130

upstream raw materials:

ethanol

3-(2-amino-4-methyl-anilino)-2-chloro-crotonic acid ethyl ester

2-amino-4-methylacetanilide

3-(2-amino-4-methyl-anilino)-crotonic acid ethyl ester

Downstream raw materials:

2-(5-methyl-1,3-dihydro-benzoimidazol-2-ylidene)-indan-1,3-dione

5-methyl-2-styryl-1⁽³⁾H-benzimidazole

1-benzyl-2,5-dimethyl-1H-benzoimidazole

1,2,5-Trimethyl-Benzimidazol

Refernces

• 1、 Rao,Reddy,Veeranagaiah. "Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon". . p. 446 - 448. Retrieved 2007/10/02.