Technology Process of cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine
There total 8 articles about cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; diethyl ether;
for 6h;
Heating;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 10percent HCl / Heating
2: 65 percent / dimethylformamide / 8 h / Heating
3: 86 percent / p-toluenesulfonic acid / benzene / 12 h / Heating
4: 1) hydrazine hydrate 2) 20percent NaOH / 1) ethanol, reflux, 2 h 2) water, 15 min
5: 92 percent / benzene
6: 45 percent / HCl / diethyl ether; CH2Cl2 / 1) 3 h, reflux; 2) 20percent HCl, 1 h, room temp.
7: 82 percent / potassium carbonate / acetone
8: 85 percent / diethyl ether; tetrahydrofuran / 6 h / Heating
With
hydrogenchloride; sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / benzene
2: 45 percent / HCl / diethyl ether; CH2Cl2 / 1) 3 h, reflux; 2) 20percent HCl, 1 h, room temp.
3: 82 percent / potassium carbonate / acetone
4: 85 percent / diethyl ether; tetrahydrofuran / 6 h / Heating
With
hydrogenchloride; potassium carbonate;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetone; benzene;
