NSC 51127

Base Information

• Chemical Name: NSC 51127
• CAS No.: 5423-97-2
• Molecular Formula: C8H12 N2 O2
• Molecular Weight: 168.195
• Hs Code.: 2933599090
• Mol file: 5423-97-2.mol

Synonyms:4(1H)-Pyrimidinone,5-(ethoxymethyl)-2-methyl- (9CI); 4-Pyrimidinol, 5-(ethoxymethyl)-2-methyl-(6CI,7CI); 4-Pyrimidol, 5-(ethoxymethyl)-2-methyl- (4CI);5-(Ethoxymethyl)-2-methyl-4-pyrimidinone; NSC 13143; NSC 51126; NSC 51127

Chemical Property of NSC 51127

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 55.24000
• Density: 1.16g/cm³
• LogP: 1.02710
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

99%, ^*data from raw suppliers

5-(Ethoxymethyl)-2-methyl-4-pyrimidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Ethoxymethyl)-2-methyl-4-pyrimidinone has been shown to increase locomotor activity in mice. Intermediate in the preparation of G protein-coupled receptor kinase (GRK) inhibitor.

Technology Process of NSC 51127

There total 7 articles about NSC 51127 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetamidine hydrochloride (124-42-5) → 5-ethoxymethyl-2-methyl-3H-pyrimidin-4-one (5423-97-2)

Guidance literature:

DOI:10.1021/ja01285a026

Reference yield:

4,6-dichloro-2,5-dimethyl-pyrimidine (1780-33-2) → 5-ethoxymethyl-2-methyl-3H-pyrimidin-4-one (5423-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dibenzoyl peroxide; CCl₄; N-bromo-succinimide

2: ethanol / anschliessenden Hydrieren an Palladium/Kohle und Behandeln mit konz.HCl

With tetrachloromethane; N-Bromosuccinimide; ethanol; dibenzoyl peroxide;

Reference yield:

5-bromomethyl-4,6-dichloro-2-methyl-pyrimidine (1780-34-3) + sodium ethanolate (141-52-6) → 5-ethoxymethyl-2-methyl-3H-pyrimidin-4-one (5423-97-2)

Guidance literature:

With ethanol; anschliessenden Hydrieren an Palladium/Kohle und Behandeln mit konz.HCl;

upstream raw materials:

5-bromomethyl-4,6-dichloro-2-methyl-pyrimidine

sodium ethanolate

4-bromo-5-bromomethyl-6-chloro-2-methyl-pyrimidine

methyl acetimidate

Downstream raw materials:

5-ethoxymethyl-2-methyl-pyrimidin-4-ylamine

5-bromomethyl-2-methyl-pyrimidin-4-ylamine