6-Methoxy-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 6-Methoxy-1,2,3,4-tetrahydronaphthalene
• CAS No.: 1730-48-9
• Molecular Formula: C11H14 O
• Molecular Weight: 162.232
• Hs Code.: 29093090
• European Community (EC) Number: 217-049-0
• NSC Number: 28470
• UNII: D0XG2UMZ29
• DSSTox Substance ID: DTXSID3061920
• Nikkaji Number: J39.362B
• Wikidata: Q27275948
• ChEMBL ID: CHEMBL1797379
• Mol file: 1730-48-9.mol

Synonyms:6-Methoxy-1,2,3,4-tetrahydronaphthalene;1730-48-9;6-Methoxytetralin;1,2,3,4-Tetrahydro-6-methoxynaphthalene;Naphthalene, 1,2,3,4-tetrahydro-6-methoxy-;UNII-D0XG2UMZ29;D0XG2UMZ29;Methyl 1,2,3,4-tetrahydro-6-naphthyl ether;EINECS 217-049-0;NSC 28470;NSC-28470;7-methoxy-3,4-dihydro-1H-naphthalene;6-methoxy-1,2,3,4-tetrahydronapthalene;3-methoxy-5,6,7,8-tetrahydronaphthalene;Naphthalene,1,2,3,4-tetrahydro-6-methoxy-;EC 217-049-0;NSC28470;SCHEMBL577378;METHOXYTETRALINE, BETA-;CHEMBL1797379;DTXSID3061920;SCHEMBL12015206;MFCD00001737;AKOS009031500;1,3,4-Tetrahydro-6-methoxynaphthalene;6-Methoxy-1,3,4-tetrahydronaphthalene;7-methoxy-1,2,3,4-tetrahydronaphthalene;BS-23439;Naphthalene,2,3,4-tetrahydro-6-methoxy-;6-methoxy-1,2,3,4-tetrahydro-naphthalene;CS-0204248;FT-0621178;M0765;5,6,7,8-tetrahydro-2-naphthol methyl ether;Y10210;2-METHOXY-5,6,7,8-TETRAHYDRONAPHTHALENE;W-109702;Q27275948

Chemical Property of 6-Methoxy-1,2,3,4-tetrahydronaphthalene

Chemical Property:

• Vapor Pressure: 0.0072mmHg at 25°C
• Melting Point: 134-137 °C
• Refractive Index: n20/D 1.54(lit.)
• Boiling Point: 278.5°Cat760mmHg
• Flash Point: 105.9°C
• PSA: 9.23000
• Density: 1.012g/cm³
• LogP: 2.57400
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 162.104465066
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

99.9% ^*data from raw suppliers

6-Methoxytetralin ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Naphthalenes
• Canonical SMILES: COC1=CC2=C(CCCC2)C=C1

Technology Process of 6-Methoxy-1,2,3,4-tetrahydronaphthalene

There total 42 articles about 6-Methoxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (16821-32-2) → 6-methoxy-1,2,3,4-tetrahydronaphthalene (1730-48-9)

Guidance literature:

With palladium dichloride; In methanol; at 40 ℃; for 18h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/adsc.201200832

Reference yield: 95.0%

tri-n-butyl-tin hydride (688-73-3) + 6'-methoxy-3',4'-dihydro-2'H-spiro[1,3-dithiolane-2,1'-naphthalene] (73622-41-0) → ethane (74-84-0) + 6-methoxy-1,2,3,4-tetrahydronaphthalene (1730-48-9) + bis(tributyltin)sulfide (4808-30-4)

Guidance literature:

2,2'-azobis(isobutyronitrile); In benzene; at 80 ℃; for 1.5h; Product distribution;

DOI:10.1021/jo01305a004

Reference yield: 95.0%

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 6-methoxy-1,2,3,4-tetrahydronaphthalene (1730-48-9)

Guidance literature:

With palladium dichloride; In methanol; at 40 ℃; for 24h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/adsc.201200832

upstream raw materials:

5,6,7,8-Tetrahydro-2-naphthol

methyl bromide

methylene chloride

2-Methoxynaphthalene

Downstream raw materials:

5,6,7,8-Tetrahydro-2-naphthol

3-methyl-phenol

p-cresol

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Refernces

• 1、 De, R.,Bhattacharyya, S.,Ganguly, T.. "Experimental investigation of excited state electron transfer reactions between some bicyclic molecules and tetracyanoquinodimethane (TCNQ)". . p. 2155 - 2166. Retrieved 1994.
• 2、 Johansson,Aujard,R?me,Anke,Sterner. "Synthesis of decaline analogues of isovelleral". . p. 984 - 989. Retrieved 2005.
• 3、 Gelis, Coralie,Heusler, Arne,Nairoukh, Zackaria,Glorius, Frank. "Catalytic Transfer Hydrogenation of Arenes and Heteroarenes". supporting information. p. 14090 - 14094. Retrieved 2020/10/19.
• 4、 Znidar, Desiree,O'Kearney-Mcmullan, Anne,Munday, Rachel,Wiles, Charlotte,Poechlauer, Peter,Schmoelzer, Christoph,Dallinger, Doris,Kappe, C. Oliver. "Scalable Wolff-Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor". . p. 2445 - 2455. Retrieved 2019/11/03.