N-methyl-6,7-(methylenedioxy)-1-naphthylamine

Base Information

• Chemical Name: N-methyl-6,7-(methylenedioxy)-1-naphthylamine
• CAS No.: 219781-97-2
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.225
• Mol file: 219781-97-2.mol

Synonyms:N-methyl-6,7-(methylenedioxy)-1-naphthylamine

Chemical Property of N-methyl-6,7-(methylenedioxy)-1-naphthylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-6,7-(methylenedioxy)-1-naphthylamine

There total 1 articles about N-methyl-6,7-(methylenedioxy)-1-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-benzyl-N-methyl-2-bromo-6,7-methylenedioxy-1-naphthylamine (748875-11-8) → N-methyl-6,7-(methylenedioxy)-1-naphthylamine (219781-97-2) + N-benzyl-6,7-methylenedioxy-1-naphthylamine

Guidance literature:

With potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide; for 4h; Heating;

DOI:10.1055/s-2004-822371

Reference yield: 98.0%

6-bromo-2,3-dimethoxybenzyl bromide (175844-54-9) + N-methyl-6,7-(methylenedioxy)-1-naphthylamine (219781-97-2) → N-(6-bromo-2,3-dimethoxybenzyl)-N-methyl-6,7-methylenedioxy-1-naphthylamine (610788-51-7)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1055/s-2003-39911 DOI:10.1055/s-2004-822371

Reference yield: 89.0%

1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene (53207-00-4) + N-methyl-6,7-(methylenedioxy)-1-naphthylamine (219781-97-2) → N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine (1449388-29-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo400890k

upstream raw materials:

N-benzyl-N-methyl-2-bromo-6,7-methylenedioxy-1-naphthylamine

Downstream raw materials:

6-[(trifluoromethanesulfonyl)oxy]-2,3-dimethoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

2-[(trifluoromethanesulfonyl)oxy]-4,5-dimethoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

6-bromo-3-isopropoxy-2-methoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

N-(6-bromo-2,3-dimethoxybenzyl)-N-methyl-6,7-methylenedioxy-1-naphthylamine

Refernces