Technology Process of 2-{1-[3-(3,4-Difluoro-benzyloxy)-phenyl]-1-methoxy-propyl}-thiazole
There total 10 articles about 2-{1-[3-(3,4-Difluoro-benzyloxy)-phenyl]-1-methoxy-propyl}-thiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
for 18h;
Ambient temperature;
DOI:10.1021/jm00111a038
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h
3: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C
4: 91 percent / diethyl ether / 1 h / Ambient temperature
5: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h
6: 76 percent / H2 / 30percent Pd/C / ethyl acetate
7: 87 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
With
n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h
2: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C
3: 91 percent / diethyl ether / 1 h / Ambient temperature
4: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h
5: 76 percent / H2 / 30percent Pd/C / ethyl acetate
6: 87 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature
With
n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide;
palladium on activated charcoal;
In
diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00111a038