Morin

Base Information

• Chemical Name: Morin
• CAS No.: 480-16-0
• Molecular Formula: C15H10O7
• Molecular Weight: 302.24
• Hs Code.: 29329990
• Mol file: 480-16-0.mol

Synonyms:Flavone,2',3,4',5,7-pentahydroxy- (8CI);2',3,4',5,7-Pentahydroxyflavone;2',4',3,5,7-Pentahydroxyflavone;2'-Hydroxypelargidenolon 1522;3,5,7,2',4'-Pentahydroxyflavone;3,5,7,2',4'-Pentahydroxyflavonol;C.I. 75660;C.I. Natural Yellow 11;LY 002079;NSC 19801;

Chemical Property of Morin

Chemical Property:

• Appearance/Colour: yellow to brown powder
• Vapor Pressure: 2.94E-17mmHg at 25°C
• Melting Point: 299-300 °C (dec.)(lit.)
• Refractive Index: 1.823
• Boiling Point: 645.5 °C at 760 mmHg
• PKA: 6.30±0.40(Predicted)
• Flash Point: 249.3 °C
• PSA: 131.36000
• Density: 1.799 g/cm³
• LogP: 1.98800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: methanol: 50 mg/mL
• Water Solubility.: 0.25g/L(20 oC)

Purity/Quality:

99% ^*data from raw suppliers

Morin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36-45

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: P450 and ATPase inhibitor Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical] Morin is a polyphenolic flavonoid with radical scavenging ability. In addition it maintains the potential for suppression of lipopolysaccharide-induced neuroinflammation.

Technology Process of Morin

There total 15 articles about Morin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(2,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-chromen-4-one (84757-50-6) → morin (480-16-0)

Guidance literature:

With pyridine hydrochloride; at 220 ℃; for 0.25h; Sealed tube;

DOI:10.1016/j.tet.2017.05.022

Reference yield:

morin 3-O-α-L-rhamnopyranoside (1173997-99-3) → L-Rhamnose (3615-41-6,478518-52-4) + morin (480-16-0)

Guidance literature:

With hydrogenchloride; water; at 85 ℃; for 2h;

DOI:10.1248/cpb.57.280

Reference yield:

C15H12O6 → morin (480-16-0)

Guidance literature:

With pyridine; dihydrogen peroxide; potassium hydroxide; In water; for 0.0833333h; Cooling with ice;

DOI:10.1007/s00044-016-1510-5

upstream raw materials:

morin 3-O-α-L-rhamnopyranoside

2,4,6-trihydroxyacetophenone

2,4-Dihydroxybenzaldehyde

2-(2,4-dimethoxyphenyl)-3-hydroxy-5,7-dimethoxy-4H-chromen-4-one

Downstream raw materials:

pentamethyl morin

4-hydroxysalicylic acid

oxalic acid

recorcinol

Refernces

• 1、 Sheng, Xiao,Jia, Xin-Yu,Tang, Fei,Wang, Yang,Hou, Ai-Jun. "The total synthesis of (±)-sanggenol F". . p. 3485 - 3491. Retrieved 2017/06/01.
• 2、 Yen, Chiao-Ting,Hsieh, Pei-Wen,Hwang, Tsong-Long,Lan, Yu-Hsuan,Chang, Fang-Rong,Yang-Chang. "Flavonol glycosides from muehlenbeckia platyclada and their anti-inflammatory activity". experimental part. p. 280 - 282. Retrieved 2009/10/15.