Trisialoganglioside GT1b

Base Information

• Chemical Name: Trisialoganglioside GT1b
• CAS No.: 59247-13-1
• Molecular Formula: C88H157N5O44
• Molecular Weight: 1989.19528
• Hs Code.: 29400090
• Mol file: 59247-13-1.mol

Synonyms:ganglioside GT1b;ganglioside GT1c;ganglioside, GT1;ganglioside, GT1a;GT(1)ganglioside;GT1b ganglioside;polysialoganglioside;trisialaoganglioside GT1a;trisialoganglioside GT1;trisialoganglioside GT1b

Chemical Property of Trisialoganglioside GT1b

Chemical Property:

• Appearance/Colour: lyophilized powder
• PSA: 841.40000
• LogP: -3.76860
• Storage Temp.: −20°C
• Solubility.: DMSO: soluble
• XLogP3: -8.5
• Hydrogen Bond Donor Count: 30
• Hydrogen Bond Acceptor Count: 47
• Rotatable Bond Count: 62
• Exact Mass: 1988.0201433
• Heavy Atom Count: 137
• Complexity: 3520

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ganglioside GT1b, Trisodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(C(C=CCCCCCCCCCCCCC)O)OC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5(CC(C(C(O5)C(C(O)OC6(CC(C(C(O6)C(C(CO)O)O)N)O)C(=O)O)O)N)O)C(=O)O)O)NC(=O)C)OC7(CC(C(C(O7)C(C(CO)O)O)N)O)C(=O)O)O)O)O
• Isomeric SMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(C(/C=C/CCCCCCCCCCCCC)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2[C@H]([C@@H]([C@@H]([C@@H](O2)CO)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H](O3)CO)O)O[C@@H]4[C@H]([C@@H]([C@@H]([C@@H](O4)CO)O)O[C@]5(C[C@@H]([C@H]([C@@H](O5)C(C(O)O[C@]6(C[C@@H]([C@H]([C@@H](O6)C(C(CO)O)O)N)O)C(=O)O)O)N)O)C(=O)O)O)NC(=O)C)O[C@]7(C[C@@H]([C@H]([C@@H](O7)C(C(CO)O)O)N)O)C(=O)O)O)O)O
• Uses: Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. Ganglioside GT1b has inhibitory effects towards human humoral immune responses. At 0.1-10 μM, it can inhibit spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells. It has also been proposed as a host cell receptor for the Merkel cell polyomavirus and as a means to enable the initiation of an infection leading to Merkel cell carcinoma.[Cayman Chemical] Ganglioside GT1b trisodium salt (bovine brain) is a glycosphingolipid neuroprotectant.