phthalyl-DL-valine acid chloride

Base Information

• Chemical Name: phthalyl-DL-valine acid chloride
• CAS No.: 64404-11-1
• Molecular Formula: C₁₃H₁₂ClNO₃
• Molecular Weight: 265.696
• Mol file: 64404-11-1.mol

Synonyms:phthalyl-DL-valine acid chloride

Chemical Property of phthalyl-DL-valine acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phthalyl-DL-valine acid chloride

There total 1 articles about phthalyl-DL-valine acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → phthalyl-DL-valine acid chloride (64404-11-1)

Guidance literature:

Multi-step reaction with 2 steps

2: SOCl₂

With thionyl chloride;

DOI:10.1007/BF00959578

Reference yield: 80.0%

aniline (62-53-3) + phthalyl-DL-valine acid chloride (64404-11-1) → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-N-phenyl-butyramide (140244-49-1)

Guidance literature:

In benzene; for 0.5h; Heating;

Reference yield: 76.0%

4-amino-4'-nitrodiphenyl sulfide (101-59-7) + phthalyl-DL-valine acid chloride (64404-11-1) → 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-N-[4-(4-nitro-phenylsulfanyl)-phenyl]-butyramide (78428-15-6)

Guidance literature:

With triethylamine; In 1,4-dioxane; Ambient temperature;

upstream raw materials:

phthalic anhydride

Downstream raw materials:

N,N-phthaloyl-DL-thiovaline-S-(2,4,5-trichloro-phenyl ester)

α-Phthalimido-β-methylbutyraldehyd

N-[3-isopropyl-2-(4-methoxy-phenyl)-4-oxo-1-(4-p-tolyl-thiazol-2-yl)-azetidin-3-yl]-phthalimide

N-[3-isopropyl-2-(2-nitro-phenyl)-4-oxo-1-(4-phenyl-thiazol-2-yl)-azetidin-3-yl]-phthalimide

Refernces

• 1、 Bauer, Adriano,Borsos, Eszter,Maulide, Nuno. "A Novel Class of 7-Membered Heterocyclic Compounds". . p. 3971 - 3974. Retrieved 2020/05/25.
• 2、 Tolstikov, G. A.,Galin, F. Z.,Lakeev, S. N.,Khalilov, L. M.,Sultanova, V. S.. "SULFUR YLIDES. 3. SYNTHESIS OF KETO-GROUP STABILIZED AMINO-CONTAINING SULFUR YLIDES FROM AMINO ACIDS". . p. 535 - 541. Retrieved 2007/10/02.