2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone

Base Information

• Chemical Name: 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone
• CAS No.: 251326-30-4
• Molecular Formula: C₁₈H₁₄O₂
• Molecular Weight: 262.308
• Mol file: 251326-30-4.mol

Synonyms:2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone

Chemical Property of 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone

There total 3 articles about 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(p-tolyl)-2-nitropropene (52287-56-6,29816-55-5) + o-phthalic dicarboxaldehyde (643-79-8) → 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone (251326-30-4)

Guidance literature:

1-(p-tolyl)-2-nitropropene; o-phthalic dicarboxaldehyde; With C₈H₁₃NOS; In dichloromethane; for 0.5h; Inert atmosphere;

With caesium carbonate; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acs.joc.8b01503

Reference yield: 26.0%

menadione (58-27-5,34524-96-4) + p-Toluic acid (99-94-5) → 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone (251326-30-4)

Guidance literature:

With ammonium peroxydisulfate; In water; acetonitrile; at 100 ℃; for 5h;

DOI:10.1039/c7cc03910g

Reference yield:

di-(4-methylbenzoyl)peroxide (895-85-2) + menadione (58-27-5,34524-96-4) → 2-methyl-3-(4-methylphenyl)-1,4-naphthoquinone (251326-30-4)

Guidance literature:

With diethyl ether; acetic acid; at 105 - 120 ℃;

upstream raw materials:

di-(4-methylbenzoyl)peroxide

menadione

p-Toluic acid

1-(p-tolyl)-2-nitropropene

Downstream raw materials:

1,2-Bis-(3-p-tolyl-1,4-napohthachinon-2-yl)-ethan

Refernces

• 1、 Sato, Naoko,Li, Wei,Takemoto, Hiroaki,Takeuchi, Mio,Nakamura, Ai,Tokura, Emi,Akahane, Chie,Ueno, Kanako,Komatsu, Kana,Kuriyama, Noriko,Onoda, Toshihisa,Higai, Koji,Koike, Kazuo. "Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent". . p. 163 - 172. Retrieved 2018/11/06.