6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid

Base Information

• Chemical Name: 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid
• CAS No.: 157337-86-5
• Molecular Formula: C₈HF₇O₂
• Molecular Weight: 262.084
• Mol file: 157337-86-5.mol

Synonyms:6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid

Chemical Property of 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid

There total 5 articles about 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

octafluoro-1,3-dihydroisobenzofuran (122180-11-4) → 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid (157337-86-5)

Guidance literature:

octafluoro-1,3-dihydroisobenzofuran; With antimony pentafluoride; at 20 ℃; for 2h;

With hydrogenchloride; Further stages.;

DOI:10.1134/s107042800802005x

Reference yield:

perfluorobenzocyclobutenone (59514-38-4) → 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid (157337-86-5) + perfluoro-2-acetyl-2'-methylbenzophenone (1105698-74-5) + 3,4,5,6-tetrafluorophthalic acid (652-03-9)

Guidance literature:

perfluorobenzocyclobutenone; With antimony pentafluoride; at 120 ℃; for 6.5h;

With hydrogenchloride; Further stages.;

DOI:10.1134/s107042800802005x

Reference yield:

4,5,6,7-tetrafluoroisobenzofuran-1,3-dione (652-12-0) → perfluorophthalide (170574-02-4) + 6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid (157337-86-5) + 3,4,5,6-tetrafluorophthalic acid (652-03-9) + decafluoro-o-xylene (1978-04-7)

Guidance literature:

4,5,6,7-tetrafluoroisobenzofuran-1,3-dione; With hydrogen fluoride; antimony pentafluoride; at 95 ℃; for 62h;

With hydrogenchloride; Further stages.;

DOI:10.1016/j.jfluchem.2006.08.006

upstream raw materials:

4,5,6,7-tetrafluoroisobenzofuran-1,3-dione

perfluorobenzocyclobutenedione

perfluorotoluene

perfluorobenzocyclobutenone

Refernces

• 1、 Zonov, Yaroslav V.,Karpov, Victor M.,Platonov, Vyacheslav E.,Rybalova, Tatjana V.,Gatilov, Yuri V.. "Oxygen replacement by fluorine in carbonyl derivatives of perfluoroaromatic compounds and isomerization of perfluoroindan-1,3-dione to perfluoro-3-methylenephthalide under the action of HF/SbF5". . p. 1574 - 1583. Retrieved 2008/09/18.