Eptazocine

Base Information

• Chemical Name: Eptazocine
• CAS No.: 72150-17-5
• Molecular Formula: BrH*C₁₅H₂₁NO
• Molecular Weight: 312.25
• Mol file: 72150-17-5.mol

Synonyms:1,6-Methano-1H-4-benzazonin-10-ol,2,3,4,5,6,7-hexahydro-1,4-dimethyl-, hydrobromide, (1S)-;1,6-Methano-1H-4-benzazonin-10-ol, 2,3,4,5,6,7-hexahydro-1,4-dimethyl-,hydrobromide, (1S,6S)- (9CI); (-)-NIH 9614; (-)-ST 2121; Eptazocinehydrobromide; MCV 4169; ST 2121; ST 2121, (-)-; l-ST 2121

Chemical Property of Eptazocine

Chemical Property:

• Vapor Pressure: 1.74E-05mmHg at 25°C
• Boiling Point: 353.6°C at 760 mmHg
• Flash Point: 166.3°C
• PSA: 23.47000
• LogP: 3.44380

Purity/Quality:

98%,99%, ^*data from raw suppliers

EPTAZOCINE HYDROBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Eptazocine hydrobromide is a centrally-acting analgesic useful in the management of post-operative and cancer pain, In animal studies eptazocine exhibits a mixed agonist/antagonist profile; its analgesic activity is reported to be mediated via opiate receptors and catecholaminergic neurons.
• Uses: Eptazocine Hydrobromide (CAS# 72150-17-5) can be used for various pharmaceutical compounds for improved skin penetration for opioid antagonists due to the presence of fatty acid esters and glycerin fatty acid esters.

Technology Process of Eptazocine

There total 67 articles about Eptazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(±)-eptazocine (54782-51-3) → (±)-eptazocine hydrobromide (72150-17-5)

Guidance literature:

With hydrogen bromide; at 20 ℃; for 0.166667h;

Reference yield: 90.0%

(-)-O-methyleptazocine (79897-14-6) → (-)-eptazocine hydrobromide (72150-17-5)

Guidance literature:

With hydrogen bromide; In water; Heating;

DOI:10.3987/COM-95-7232

Reference yield: 80.0%

(-)-(1S,6S)-2,3,4,5,6,7-hexahydro-1,4-dimethyl-10-methoxy-1,6-methano-1H-4-benzoazonine (74958-17-1) → eptazocine hydrobromide (72150-17-5)

Guidance literature:

With hydrogen bromide; In water; for 1h; Heating;

DOI:10.3987/COM-95-7232

upstream raw materials:

(-)-(1S,6S)-2,3,4,5,6,7-hexahydro-1,4-dimethyl-10-methoxy-1,6-methano-1H-4-benzoazonine

tert-Butyl-[2-(3-iodo-propyl)-5-methoxy-phenoxy]-dimethyl-silane

N-[2-((S)-7-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-ethyl]-N-methyl-acetamide

2-(tert-Butyl-dimethyl-silanyloxy)-1-[(Z)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-enyl]-4-methoxy-benzene

Refernces

• 1、 -. "Intermediates for preparing eptazocine hydrobromide and preparation methods of intermediates". Paragraph 0151; 0152. . Retrieved 2019/12/25.
• 2、 -. "Methods for preparing benzo ring derivative with benzylic quaternary carbon center and ethazocine hydrobromide". Paragraph 0204; 0205; 0206. . Retrieved 2018/10/11.