C₁₉H₂₄FN₃O₄

Base Information

• Chemical Name: C₁₉H₂₄FN₃O₄
• CAS No.: 1375143-22-8
• Molecular Formula: C₁₉H₂₄FN₃O₄
• Molecular Weight: 377.416
• Mol file: 1375143-22-8.mol

Synonyms:C₁₉H₂₄FN₃O₄

Chemical Property of C₁₉H₂₄FN₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₄FN₃O₄

There total 4 articles about C₁₉H₂₄FN₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C13H19IN2O4 (1375143-20-6) + 4-fluoroaniline (371-40-4) → C19H24FN3O4 (1375143-22-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1021/jm201301h

Reference yield:

5-[(1-(tert-butoxycarbonyl)-2(S)-azetidinyl)methoxy]-isoxazole-3-carboxylic acid ethyl ester (1354395-27-9) → C19H24FN3O4 (1375143-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: 1H-imidazole; iodine; triphenylphosphine / 20 °C / Inert atmosphere; Cooling with ice

3: potassium carbonate / acetonitrile / 20 °C

With 1H-imidazole; lithium borohydride; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm201301h

Reference yield:

2-(S)-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester (161511-85-9) → C19H24FN3O4 (1375143-22-8)

Guidance literature:

Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole; iodine; triphenylphosphine / 20 °C / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 20 °C

With 1H-imidazole; lithium borohydride; di-isopropyl azodicarboxylate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1: Mitsunobu reaction;

DOI:10.1021/jm201301h

upstream raw materials:

5-[(1-(tert-butoxycarbonyl)-2(S)-azetidinyl)methoxy]-isoxazole-3-carboxylic acid ethyl ester

5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-isoxazolylmethanol

C₁₃H₁₉IN₂O₄

4-fluoroaniline

Refernces