Technology Process of 4-(((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid trifluoroacetate
There total 17 articles about 4-(((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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1443467-69-3
4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 1-tert-butyl 2,2-dimethylsuccinate
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1443468-18-5
4-(((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid trifluoroacetate
- Guidance literature:
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In
dichloromethane;
at 20 ℃;
for 2h;
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55976-58-4
((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-9-acetoxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-3a-yl)methyl acetate
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1443468-18-5
4-(((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid trifluoroacetate
- Guidance literature:
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Multi-step reaction with 11 steps
1.1: potassium hydroxide; water / toluene; ethanol / 4 h / 20 °C
2.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
3.1: triethylamine / 60 °C
4.1: sodium tetrahydroborate; methanol; nickel dichloride / 0.17 h / 0 °C
5.1: zinc(II) chloride / methanol; 1,2-dichloro-ethane / 1 h / 80 °C
5.2: 1 h / 20 °C
6.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C
7.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
8.1: water; sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C
9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
10.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C
11.1: dichloromethane / 2 h / 20 °C
With
methanol; dmap; sodium tetrahydroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; potassium hydroxide; sodium hydroxide; nickel dichloride; zinc(II) chloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;
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(3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(hydroxymethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
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1443468-18-5
4-(((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid trifluoroacetate
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
2.1: triethylamine / 60 °C
3.1: sodium tetrahydroborate; methanol; nickel dichloride / 0.17 h / 0 °C
4.1: zinc(II) chloride / methanol; 1,2-dichloro-ethane / 1 h / 80 °C
4.2: 1 h / 20 °C
5.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C
6.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
7.1: water; sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
9.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C
10.1: dichloromethane / 2 h / 20 °C
With
methanol; dmap; sodium tetrahydroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; sodium hydroxide; nickel dichloride; zinc(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;