8-fluorooctanoic acid

Base Information

• Chemical Name: 8-fluorooctanoic acid
• CAS No.: 353-25-3
• Molecular Formula: C8H15 F O2
• Molecular Weight: 162.204
• Hs Code.: 2915900090
• Mol file: 353-25-3.mol

Synonyms:8-Fluorooctanoicacid

Chemical Property of 8-fluorooctanoic acid

Chemical Property:

• Vapor Pressure: 0.00383mmHg at 25°C
• Melting Point: 35°C
• Boiling Point: 259.7°Cat760mmHg
• PKA: 4.77±0.10(Predicted)
• Flash Point: 110.8°C
• PSA: 37.30000
• Density: 1.009g/cm³
• LogP: 2.38110

Purity/Quality:

98%min ^*data from raw suppliers

8-FLUOROOCTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Fluorooctanoic acid is used in the synthesis of a monofluoro 3-?alkyl-?2-?hydroxy-?1,?4-?naphthoquinone as a potential anti-malarial drug. It is also used in site-specific fluorination of biomolecules catalyzed by lipoic acid ligase.

Technology Process of 8-fluorooctanoic acid

There total 1 articles about 8-fluorooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-7-fluoro-heptane (334-43-0) + methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) → azelaic acid (123-99-9,26776-28-3) + 8-fluoroocatanoic acid (353-25-3)

Guidance literature:

With diethyl ether; magnesium; anschliessend mit wss.Schwefelsaeure;

DOI:10.1021/jo01114a015

Reference yield:

8-fluoroocatanoic acid (353-25-3) + Ac-GFEIDKVWYDLDA-OH → [19F]-FA-LAP

Guidance literature:

With bacterial enzyme lipoic acid ligase LplA; magnesium acetate; ATP; In aq. phosphate buffer; at 30 ℃; for 0.5h; pH=7.4; Inert atmosphere; Enzymatic reaction;

Reference yield:

8-fluoroocatanoic acid (353-25-3) → (S)-4-benzyl-3-(8-fluorooctanoyl)oxazolidin-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere

With dmap; oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2015.10.054

upstream raw materials:

1-chloro-7-fluoro-heptane

methylammonium carbonate

Downstream raw materials:

11-fluoro-3-methyl-undecanoic acid

1,14-Difluor-tetradecan

3-O-benzyl-1-(8-fluorooctanoyl)glycerol

3-O-benzyl-2-(8-fluorooctanoyl)-1-palmitoylglycerol