Nitrilotriacetamide

Base Information

• Chemical Name: Nitrilotriacetamide
• CAS No.: 4862-18-4
• Molecular Formula: C6H12N4O3
• Molecular Weight: 188.186
• European Community (EC) Number: 225-469-0
• NSC Number: 108223
• DSSTox Substance ID: DTXSID7049689
• Nikkaji Number: J221.290K
• Wikidata: Q81976643
• Mol file: 4862-18-4.mol

Synonyms:nitrilotriacetamide;ntam cpd

Chemical Property of Nitrilotriacetamide

Chemical Property:

• Boiling Point: 577.3oC at 760 mmHg
• Flash Point: 302.9oC
• PSA: 132.51000
• Density: 1.371g/cm3
• LogP: -1.15480
• XLogP3: -2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 188.09094026
• Heavy Atom Count: 13
• Complexity: 190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)N)N(CC(=O)N)CC(=O)N
• Use Description: 2,2',2''-Nitrilotris(acetamide), also known as NTA (Nitrilotriacetamide), serves various purposes across different fields. In the realm of chemistry, it acts as a chelating agent, forming stable complexes with metal ions, which makes it valuable in analytical chemistry, particularly in metal ion titrations and trace metal analysis. In the field of agriculture, it may be used as a complexing agent in fertilizers to improve the solubility and bioavailability of essential micronutrients for plants. Additionally, in water treatment and environmental science, NTA can be employed as a chelating agent for the removal of heavy metals from wastewater, aiding in the mitigation of water pollution. Its multifaceted contributions underscore its significance in chemistry, agriculture, and environmental science, offering solutions for metal complexation, nutrient delivery, and water quality management in these diverse fields.

Technology Process of Nitrilotriacetamide

There total 7 articles about Nitrilotriacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

nitrilotriacetonitrile (7327-60-8) → nitrilotriacetic acid triamide (4862-18-4)

Guidance literature:

With sulfuric acid; for 0.5h; 1.) room temperature, 2.) 40 deg C, 10 min, 3. 60 deg C, 4.) -> room temperature;

DOI:10.1080/00397919508011491

Reference yield:

ethanol (64-17-5) + ammonia (7664-41-7) + Chloroacetamide (79-07-2) → nitrilotriacetic acid triamide (4862-18-4) + 2,2′-iminobis(acetamide) (21954-96-1) + H-Gly-NH2 (598-41-4)

Guidance literature:

at 100 ℃;

DOI:10.1002/ardp.19092470328

Reference yield:

Chloroacetamide (79-07-2) → nitrilotriacetic acid triamide (4862-18-4)

Guidance literature:

With ethanol; ammonia; at 100 ℃;

DOI:10.1002/ardp.19092470328

upstream raw materials:

triethyl nitrilotriacetate

Chloroacetamide

nitrilotriacetonitrile

2,2',2''-triaminotriethylamine

Downstream raw materials:

4-(carbamoylmethyl)piperazine-2,6-dione

Refernces

• 1、 Mac Williams et al.. "". . p. 1546. Retrieved 1965.
• 2、 Smith,Cramer,Sucheck,Skrzypczak-Jankun. "Facile synthesis of substituted nitrilotriacetamides". . p. 7765 - 7768. Retrieved 2007/10/02.