7-ACETOXY-4-BROMOMETHYLCOUMARIN

Base Information

• Chemical Name: 7-ACETOXY-4-BROMOMETHYLCOUMARIN
• CAS No.: 2747-04-8
• Molecular Formula: C12H9 Br O4
• Molecular Weight: 297.1
• Hs Code.: 2932209090
• Mol file: 2747-04-8.mol

Synonyms:Coumarin,4-(bromomethyl)-7-hydroxy-, acetate (7CI); 4-Bromomethyl-7-acetoxycoumarin;7-Acetoxy-4-(bromomethyl)coumarin

Chemical Property of 7-ACETOXY-4-BROMOMETHYLCOUMARIN

Chemical Property:

• Appearance/Colour: Off-White Crystalline Solid
• Vapor Pressure: 4.46E-07mmHg at 25°C
• Melting Point: 180-182°C
• Boiling Point: 414.4°Cat760mmHg
• Flash Point: 204.4°C
• PSA: 56.51000
• Density: 1.589g/cm³
• LogP: 2.61320

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromomethyl-7-Acetoxycoumarin ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 22-26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-ACETOXY-4-BROMOMETHYLCOUMARIN is a fluorescent reagent used for labelling carboxylic acids

Technology Process of 7-ACETOXY-4-BROMOMETHYLCOUMARIN

There total 2 articles about 7-ACETOXY-4-BROMOMETHYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-methylumbelliferyl acetate (2747-05-9) → 7-acetoxy-4-bromomethyl-2H-1-benzopyran-2-one (2747-04-8)

Guidance literature:

Reference yield:

→ 7-acetoxy-4-bromomethyl-2H-1-benzopyran-2-one (2747-04-8)

Guidance literature:

7-Acetoxy-4-methyl-cumarin, Pyridin, Brom, wss. H2O2;

Reference yield: 82.9%

7-acetoxy-4-bromomethyl-2H-1-benzopyran-2-one (2747-04-8) → 4-(bromomethyl)-7-hydroxy-2H-chromen-2-one (161798-25-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1021/ma061175h

upstream raw materials:

4-methylumbelliferyl acetate

Downstream raw materials:

4-(bromomethyl)-7-hydroxy-2H-chromen-2-one

7-hydroxy-4-(hydroxylmethyl)-2H-chromen-2-one

Refernces

• 1、 -. "Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds". . . Retrieved 2008/06/13.