2-Amino-3-hydroxypropanamide hydrochloride

Base Information

• Chemical Name: 2-Amino-3-hydroxypropanamide hydrochloride
• CAS No.: 65414-74-6
• Molecular Formula: C3H8 N2 O2 . Cl H
• Molecular Weight: 140.57
• Hs Code.: 29241990
• European Community (EC) Number: 265-753-1
• NSC Number: 206312
• DSSTox Substance ID: DTXSID10984029
• Mol file: 65414-74-6.mol

Synonyms:2-amino-3-hydroxypropanamide hydrochloride;89170-23-0;MFCD00067559;H-Ser-NH HCl;(S)-2-Amino-3-hydroxypropionamide hydrochloride;EINECS 265-753-1;MFCD00067560;(S)-2-Amino-3-hydroxypropionamide HCl;L-Serinamidehydrochloride;SCHEMBL853081;DTXSID10984029;NSC206312;AKOS024124078;NSC-206312;2-amino-3-hydroxypropanamidehydrochloride;65414-73-5;AM806435;SY034139;CS-0161462;FT-0628012;E77090;EN300-297815;2-AMINO-3-HYDROXY-PROPIONAMIDE HYDROCHLORIDE;2-Amino-3-hydroxypropanimidic acid--hydrogen chloride (1/1)

Chemical Property of 2-Amino-3-hydroxypropanamide hydrochloride

Chemical Property:

• Appearance/Colour: White powder.
• Vapor Pressure: 8.9E-10mmHg at 25°C
• Melting Point: 185-188 ºC
• Boiling Point: 444.7oC at 760 mmHg
• Flash Point: 222.8oC
• PSA: 89.34000
• LogP: -0.00610
• Storage Temp.: Store at RT.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 140.0352552
• Heavy Atom Count: 8
• Complexity: 73.3

Purity/Quality:

98%-102% ^*data from raw suppliers

L-Serine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(=O)N)N)O.Cl

Technology Process of 2-Amino-3-hydroxypropanamide hydrochloride

There total 1 articles about 2-Amino-3-hydroxypropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) → L-serinamide hydrochloride (65414-74-6)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 48h;

Reference yield: 91.0%

cinnamyl methyl carbonate (85217-69-2,87802-71-9) + L-serinamide hydrochloride (65414-74-6) → (-)-(S)-(3-hydroxy-2-(((S)-1-phenylallyl)amino)propanamide) (1265877-20-0)

Guidance literature:

With potassium phosphate; dichlorobis(η-4-dibenzo[a,e]cyclooctatetraene)diiridium; N-butylamine; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In dimethyl sulfoxide; at 55 ℃; for 16h; optical yield given as %de; regioselective reaction;

DOI:10.1002/adsc.201000721

Reference yield: 85.0%

L-serinamide hydrochloride (65414-74-6) + (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl (131949-12-7) → (1H-indol-3-ylcarbonyl)-Asp(Ser-NH2)-Phe-NMeBzl

Guidance literature:

With benzotriazol-1-ol; In N,N-dimethyl-formamide; 1.) 0 deg C, 1 h, 2.) RT, 3 h;

DOI:10.1021/jm00068a003

upstream raw materials:

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Downstream raw materials:

Z-Ser-Ser-NH₂

(3S)-3-hydroxymethyl-2,5-dioxohexahydro-1H-pyrrolo[1,2-a]-imidazole

DNP-prolylserinamide

4,5-difluoro-3-(3,5-dimethylphenylsulfonyl)-indole-2-carboxyserinamide

Refernces