Renese

Base Information

• Chemical Name: Renese
• CAS No.: 346-18-9
• Molecular Formula: C₁₁H₁₃ClF₃N₃O₄S₃
• Molecular Weight: 439.888
• European Community (EC) Number: 206-468-4
• NSC Number: 108161
• UNII: 36780APV5N,SWY93BD8RL
• DSSTox Substance ID: DTXSID6025939
• Nikkaji Number: J2.035D
• Wikipedia: Polythiazide
• Wikidata: Q7227099
• NCI Thesaurus Code: C47676
• Pharos Ligand ID: UPPK59ZV4ZU2
• Metabolomics Workbench ID: 43493
• ChEMBL ID: CHEMBL1587
• Mol file: 346-18-9.mol

Synonyms:Polythiazide;Renese

Chemical Property of Renese

Chemical Property:

• Vapor Pressure: 1.88E-13mmHg at 25°C
• Melting Point: 202.5°
• Refractive Index: 1.6100 (estimate)
• Boiling Point: 580.1°Cat760mmHg
• PKA: pKa 9.58(H2O,t =25) (Uncertain)
• Flash Point: 304.7°C
• PSA: 151.63000
• Density: 1.598g/cm³
• LogP: 4.59280
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 438.9708816
• Heavy Atom Count: 25
• Complexity: 692

Purity/Quality:

99%, ^*data from raw suppliers

Polythiazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F
• Description: Polythiazide exhibits a more pronounced antihypertensive effect than chlorothiazide and it may be used independently for the same indications as the aforementioned drugs. However, it is primarily used as an ingredient of a combination drugs intended for lowering pressure, in particular in minizide, which is a combination of prazozine and polythiazide.
• Uses: Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.
• Therapeutic Function: Diuretic

Technology Process of Renese

There total 1 articles about Renese which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ polythiazide (346-18-9,96783-10-7,96783-11-8)

Guidance literature: