Technology Process of N-[3-(5-hydroxy-2-naphthyl)phenyl]methanesulfonamide
There total 5 articles about N-[3-(5-hydroxy-2-naphthyl)phenyl]methanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
1,2-dimethoxyethane; water;
at 150 ℃;
for 0.416667h;
under 11251.1 Torr;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.bmc.2010.12.013
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 0.42 h / 150 °C / 11251.1 Torr / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); lithium carbonate; sodium carbonate; lithium bromide;
In
1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
2: Suzuki coupling;
DOI:10.1016/j.bmc.2010.12.013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 0.5 h / 0 °C
2: hydrogenchloride; bromine / tetrachloromethane; diethyl ether / 0.5 h / 0 - 5 °C
3: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux
4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 0.42 h / 150 °C / 11251.1 Torr / Inert atmosphere; Microwave irradiation
With
pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); bromine; lithium carbonate; sodium carbonate; lithium bromide;
In
tetrachloromethane; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide;
4: Suzuki coupling;
DOI:10.1016/j.bmc.2010.12.013