2,6-piperidinedicarboxylic acid

Base Information

• Chemical Name: 2,6-piperidinedicarboxylic acid
• CAS No.: 499-82-1
• Molecular Formula: C₇H₁₁NO₄
• Molecular Weight: 173.169
• Hs Code.: 2933399090
• Mol file: 499-82-1.mol

Synonyms:2,6-piperidinedicarboxylic acid

Chemical Property of 2,6-piperidinedicarboxylic acid

Chemical Property:

• Vapor Pressure: 3.29E-08mmHg at 25°C
• Boiling Point: 419.4°Cat760mmHg
• PKA: 1.94±0.40(Predicted)
• Flash Point: 207.5°C
• PSA: 86.63000
• Density: 1.363g/cm³
• LogP: -0.00490
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Piperidine-2,6-dicarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-piperidinedicarboxylic acid

There total 4 articles about 2,6-piperidinedicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.2%

2,6-diaminopimelic acid (922-54-3,2577-62-0,14289-34-0,17121-19-6,583-93-7,1356383-43-1) → (+/-)-trans-piperidine-2,6-dicarboxylic acid (499-82-1,59234-40-1,69779-51-7,98976-31-9,147486-80-4) + cis-meso-piperidine-2,6-dicarboxylic acid (59234-40-1,429661-20-1)

Guidance literature:

With sodium hydroxide; cadmium(II) sulphide; at 24.9 ℃; for 24h; Irradiation;

DOI:10.1246/cl.1995.803

Reference yield: 14.0%

trans-2,6-piperidinedicarboxamide (99669-83-7) → (+/-)-trans-piperidine-2,6-dicarboxylic acid (499-82-1,59234-40-1,69779-51-7,98976-31-9,147486-80-4)

Guidance literature:

With barium dihydroxide; In water; for 2h; Heating;

DOI:10.1016/0040-4020(95)00618-I

Reference yield:

2,6-diaminopimelic acid (922-54-3,2577-62-0,14289-34-0,17121-19-6,583-93-7,1356383-43-1) → Δ1-Tetrahydrodipicolinsaeure (2353-17-5) + (+/-)-trans-piperidine-2,6-dicarboxylic acid (499-82-1,59234-40-1,69779-51-7,98976-31-9,147486-80-4) + cis-meso-piperidine-2,6-dicarboxylic acid (59234-40-1,429661-20-1)

Guidance literature:

With sodium hydroxide; platinum(IV) oxide; cadmium(II) sulphide; In water; at 24.84 ℃; for 20h; Title compound not separated from byproducts.; Irradiation;

DOI:10.1039/b0069671

upstream raw materials:

cis-meso-piperidine-2,6-dicarboxylic acid

2,6-diaminopimelic acid

trans-2,6-piperidinedicarboxamide

Refernces

• 1、 Ohtani, Bunsho,Kusakabe, Satoshi,Nishimoto, Sei-ichi,Matsumura, Michio,Nakato, Yoshihiro. "Improvement of photocatalytic activity and product selectivity by cadmium metal deposited in situ on suspended cadmium(II) sulfide particles". . p. 803 - 804. Retrieved 2007/10/03.
• 2、 Chrystal, Ewan J. T.,Couper, Lynda,Robins, David J.. "Synthesis of a key intermediate in the diaminopimelate pathway to L-lysine: 2,3,4,5-tetrahydrodipicolinic acid". . p. 10241 - 10252. Retrieved 2007/10/02.