Tilmicosin phosphate salt

Base Information

• Chemical Name: Tilmicosin phosphate salt
• CAS No.: 137330-13-3
• Molecular Formula: C₄₆H₈₀N₂O₁₃*H₃O₄P
• Molecular Weight: 967.142
• European Community (EC) Number: 641-061-9
• Mol file: 137330-13-3.mol

Synonyms:137330-13-3;Tilmicosin phosphate salt;LY-177370 phosphate;EL-870 phosphate;A807238;20-deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin phosphate;15-[(3,4-dimethoxy-6-methyl-5-oxidanyl-oxan-2-yl)oxymethyl]-6-[4-(dimethylamino)-6-methyl-3,5-bis(oxidanyl)oxan-2-yl]oxy-7-[2-(3,5-dimethylpiperidin-1-yl)ethyl]-16-ethyl-5,9,13-trimethyl-4-oxidanyl-1-oxacyclohexadeca-11,13-diene-2,10-dione;phosphoric aci;6-[[4-(dimethylamino)-3,5-dihydroxy-6-methyl-2-oxanyl]oxy]-7-[2-(3,5-dimethyl-1-piperidinyl)ethyl]-16-ethyl-4-hydroxy-15-[(5-hydroxy-3,4-dimethoxy-6-methyl-2-oxanyl)oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione;phosphoric acid

Chemical Property of Tilmicosin phosphate salt

Chemical Property:

• Appearance/Colour: light yellow powder
• Vapor Pressure: 2.91E-11mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 926.6 °C at 760 mmHg
• Flash Point: 514.2 °C
• PSA: 273.72000
• Density: 1.219 g/cm³
• LogP: 2.35070
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Very Slightly)
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 12
• Exact Mass: 966.54293618
• Heavy Atom Count: 66
• Complexity: 1470

Purity/Quality:

99%, ^*data from raw suppliers

Tilmicosin phosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O
• Uses: Tilmicosin phosphate is a salt of the semi-synthetic antibiotic derivative of desmycosin (tylosin B), a minor co-metabolite of tylosin, prepared by mixing the active tilmicosin with phosphoric acid to provide improved solubility and enhanced pharmacokinetics. Tilmicosin is a broad sepctrum antibiotic, providing good protection against Pasteurella in livestock. Tilmicosin Phosphate Salt is the phosphate salt of the semi-synthetic antibiotic derivative. It can be used in biological study and pharmacological activity of bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica from cattle.

Technology Process of Tilmicosin phosphate salt

There total 1 articles about Tilmicosin phosphate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tylosin tartrate + (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7) → tilmicosin phosphate (137330-13-3)

Guidance literature:

tylosin tartrate; With sulfuric acid; In water; at 45 ℃; for 2h; pH=1.9;

(3S,5R)-3,5-dimethylpiperidine; With formic acid; In ethyl acetate; at 75 ℃; for 2.5h;

With phosphorus pentoxide; water; In ethyl acetate; at 25 ℃; for 1h; Temperature; pH-value;

upstream raw materials:

(3S,5R)-3,5-dimethylpiperidine

Refernces