2-AMINO-2-METHYLPENTANOIC ACID

Base Information

• Chemical Name: 2-AMINO-2-METHYLPENTANOIC ACID
• CAS No.: 3275-37-4
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.175
• Mol file: 3275-37-4.mol

Synonyms:Norvaline,2-methyl-, L- (8CI); 2-Methyl-L-norvaline; L-a-Methylnorvaline; a-Methyl-L-norvaline

Chemical Property of 2-AMINO-2-METHYLPENTANOIC ACID

Chemical Property:

• Vapor Pressure: 0.0309mmHg at 25°C
• Boiling Point: 225.8°Cat760mmHg
• PKA: 2.58±0.40(Predicted)
• Flash Point: 90.3°C
• PSA: 63.32000
• Density: 1.041g/cm³
• LogP: 1.28880

Purity/Quality:

98%Min ^*data from raw suppliers

2-amino-2-methylpentanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-2-METHYLPENTANOIC ACID

There total 8 articles about 2-AMINO-2-METHYLPENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3S,6S)-1,4-N,N-[(S)-phenylethyl]-3,6-dipropyl-3,6-dimethylpiperazine-2,5-dione (1204593-75-8) → (S)-2-propylalanine (3275-37-4)

Guidance literature:

With water; hydrogen iodide; Reflux;

DOI:10.1007/s00726-009-0289-9

Reference yield: 89.0%

(3S,5aR,6aS,7aS)-5,5a,6,6a,7,7a-hexahydro-3,6,6,7a-tetramethyl-3-propylbicyclo[4.1.0]hept-1(6)eno[3,4-b][1,4]oxazin-2(3H)-one (1266681-12-2) → (S)-2-propylalanine (3275-37-4)

Guidance literature:

(3S,5aR,6aS,7aS)-5,5a,6,6a,7,7a-hexahydro-3,6,6,7a-tetramethyl-3-propylbicyclo[4.1.0]hept-1⁽⁶⁾eno[3,4-b][1,4]oxazin-2(3H)-one; With cesium hydroxide; water; at 70 ℃; for 2.5h;

With hydrogenchloride; In water;

DOI:10.1021/jo1022537

Reference yield:

→ (-)-2-amino-2-methyl-valeric acid (3275-37-4,5455-33-4,26287-61-6,110916-84-2)

Guidance literature:

With yeast; Sucrose;

upstream raw materials:

(1R,3R,4S)-8-phenyl-p-menthan-3-yl (2'S)-2'-amino-2'-methylpentanoate

(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen methyl(propyl)malonate

(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen allyl(methyl)malonate

(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen propylmalonate

Downstream raw materials:

(S)-α-methylnorvaline methyl ester

Refernces

• 1、 Balducci, Daniele,Lazzari, Ilaria,Monari, Magda,Piccinelli, Fabio,Porzi, Gianni. "(S)-α-methyl,α-amino acids: A new stereocontrolled synthesis". experimental part. p. 829 - 837. Retrieved 2010/09/04.