Technology Process of benzyl (2S,5R)-2-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-methylpyrrolidine-1-carboxylate
There total 6 articles about benzyl (2S,5R)-2-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-methylpyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 16h;
DOI:10.1016/j.bmc.2013.04.056
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: perchloric acid / water / 16 h / 20 °C
2.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / 48 h / 20 °C
4.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.5 h / -78 °C / Inert atmosphere
4.2: 16 h / -78 - 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / chloroform / 16 h / 50 °C
6.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
With
perchloric acid; copper(I) bromide dimethylsulfide complex; lithium triethylborohydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water;
DOI:10.1016/j.bmc.2013.04.056
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / 48 h / 20 °C
3.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.5 h / -78 °C / Inert atmosphere
3.2: 16 h / -78 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / chloroform / 16 h / 50 °C
5.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
With
copper(I) bromide dimethylsulfide complex; lithium triethylborohydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/j.bmc.2013.04.056