METHYL 2-CYANO-3,3-DI(METHYLTHIO)ACRYLATE

Base Information

• Chemical Name: METHYL 2-CYANO-3,3-DI(METHYLTHIO)ACRYLATE
• CAS No.: 3490-92-4
• Molecular Formula: C7H9NO2S2
• Molecular Weight: 203.286
• Hs Code.: 2930909090
• Mol file: 3490-92-4.mol

Synonyms:Acrylicacid, 2-cyano-3-oxo-, methyl ester, dimethyl mercaptole (7CI);1-Cyano-1-(methoxycarbonyl)-2,2-bis(methylthio)ethylene;2-Cyano-3,3-bis(methylsulfanyl)prop-2-enoic acid methyl ester;2-Cyano-3,3-di(methylthio)acrylic acid methyl ester;3,3-(Bismethylthio)-2-cyanoacrylic acid methyl ester;Methylbis(methylthio)methylenecyanoacetate;

Chemical Property of METHYL 2-CYANO-3,3-DI(METHYLTHIO)ACRYLATE

Chemical Property:

• Vapor Pressure: 0.0011mmHg at 25°C
• Melting Point: 85 °C
• Refractive Index: 1.553
• Boiling Point: 300.765 °C at 760 mmHg
• Flash Point: 135.698 °C
• PSA: 100.69000
• Density: 1.254 g/cm³
• LogP: 1.62058

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-Cyano-3,3-bis(methylthio)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-CYANO-3,3-DI(METHYLTHIO)ACRYLATE

There total 9 articles about METHYL 2-CYANO-3,3-DI(METHYLTHIO)ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.33%

carbon disulfide (75-15-0,12122-00-8) + methyl 2-cyanoacetate (105-34-0) + methyl iodide (74-88-4) → methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate (3490-92-4)

Guidance literature:

methyl 2-cyanoacetate; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Cooling with ice;

carbon disulfide; In tetrahydrofuran; mineral oil; at -20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; for 0.75h;

DOI:10.1021/ol9000679

Reference yield: 89.33%

Dimethyldisulphide (624-92-0) + methyl 2-cyanoacetate (105-34-0) + methyl iodide (74-88-4) → methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate (3490-92-4)

Guidance literature:

methyl 2-cyanoacetate; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Cooling with ice;

Dimethyldisulphide; In tetrahydrofuran; mineral oil; at 20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1021/ol403470d

Reference yield: 65.8%

carbon disulfide (75-15-0,12122-00-8) + dimethyl sulfate (77-78-1) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate (3490-92-4)

Guidance literature:

carbon disulfide; methyl 2-cyanoacetate; With potassium hydroxide; In water; N,N-dimethyl-formamide; at 25 ℃; for 1h;

dimethyl sulfate; In water; N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1039/c5ra27017k

upstream raw materials:

carbon disulfide

dimethyl sulfate

methyl 2-cyanoacetate

potassium 2-cyano-3-methoxy-3-oxoprop-1-ene-1,1-bis(thiolate)

Downstream raw materials:

methyl 3-(m-anisidino)-2-cyano-3-methylthioacrylate

6-[2-(4-methoxyphenyl)vinyl]-4-methylthio-2-oxo-2H-pyran-3-carbonitrile

5-Amino-3-methylsulfanyl-1-(toluene-4-sulfonyl)-1H-pyrazole-4-carboxylic acid methyl ester

4-methylsulfanyl-2-oxo-6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2H-pyran-3-carbonitrile

Refernces

• 1、 -. "MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF". Paragraph 0090; 0091. . Retrieved 2019/11/05.
• 2、 Jha, Ajay Kumar,Umar, Shahida,Arya, Rakesh Kumar,Datta, Dipak,Goel, Atul. "Pyrano[3,2-c] julolidin-2-ones: A novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells". . p. 4934 - 4940. Retrieved 2016/07/26.